Disilathiane as a Sulfur Source for the Construction of Isothiochromenes and Benzo[b]thiophenes by Copper-Catalyzed endo-Selective Hydrothiolation
Disilathiane as a Sulfur Source for the Construction of Isothiochromenes and Benzo[b]thiophenes by Copper-Catalyzed endo-Selective Hydrothiolation
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二硅硫烷作为硫源用于铜催化内选择性硫氢化反应构建异硫色烯和苯并[b]噻吩
DOI：
10.1055/a-1953-4534
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Ogiwara Yohei
中科院分区：
文献类型：
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作者：
Sakai Norio;Nakajima Takumi;Takeuchi Ryuki;Oomori Keita;Ishida Kento;Ogiwara Yohei
本文描述了一种铜催化的异硫色烯和苯并[B]噻吩的合成方法，该方法以1，1，1，3，3，3-六甲基二硅硫杂环己烷为硫源，通过环化反应合成异硫色烯和苯并[B]噻吩。在异硫代色烯合成中，使用二硅硫杂环丁烷作为硫源成功地控制了环化的区域选择性，以提供作为唯一产物的异硫代色烯。该方法可用于2-芳基/2-烷基苯并[B]噻吩类化合物的合成。
A copper-catalyzed construction of isothiochromenes and benzo[b]thiophenes via annulation with 1,1,1,3,3,3-hexamethyldisilathiane as a sulfur source is described. In the isothiochromene synthesis, the use of the disilathiane as a sulfur source successfully controls the regioselectivity of cyclization to afford the isothiochromene as the sole product. The present strategy can be applied to the synthesis of 2-aryl/2-alkylbenzo[b]thiophenes.