Pituitary adenomas with parasellar invasion.
Pituitary adenomas with parasellar invasion.
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DOI：
10.1007/978-3-7091-9183-5_12
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
Engelbert Knosp;Klaus Kitz;E. Steiner;Ch. Matula
中科院分区：
文献类型：
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作者：
Engelbert Knosp;Klaus Kitz;E. Steiner;Ch. Matula
垂体腺瘤延伸到鞍旁间隙，即所谓的“海绵窦”，最好使用 MRI 来证明。为了改善静脉室的描绘，必须使用非增强和增强 MRI 扫描。在 25 例经手术证实已浸润到海绵窦间隙的垂体腺瘤中，我们将 MRI 结果与手术观察结果相关联。当腺瘤包围海绵体内颈内动脉或到达动脉的外侧时，所有病例均存在浸润。 MRI 无法预测侵入的关键区域是海绵体内颈内动脉内侧和外侧之间的距离。通过单克隆抗体 KI-67 的测量可以显示，与非侵袭性腺瘤相比，浸润鞍旁间隙的垂体腺瘤具有统计学上显着更高的生长率 (p < 0.001)。这是特别令人感兴趣的，因为当存在对海绵窦空间的侵入时，手术治愈变得不太可能。
Pituitary adenomas with extension into the parasellar space, the so called “cavernous sinus” can be demonstrated best using MRI. To improve the delineation from the venous compartments the use of unenhanced and enhanced MRI scans is essential. In 25 pituitary adenomas with surgically proven infiltration into the space of the cavernous sinus we correlated the MRI findings with our surgical observations. When the adenoma encases the intracavernous internal carotid artery or reaches as far as to the lateral aspect of the artery, invasion was present in all cases. The critical area where invasion could not be predicted from MRI is the distance between the medial and the lateral aspect of the intracavernous internal carotid artery. By measurement with the monoclonal antibody KI-67 it could be shown, that pituitary adenomas infiltrating the parasellar space have a statistically significant higher growth rate (p < 0.001), compared to non-invasive adenomas. This is of special interest, because surgical cure becomes unlikely, when invasion into the space of the cavernous sinus is present.