Interferon induction by viruses. IX. Antagonistic activities of virus particles modulated interferon production.
Interferon induction by viruses. IX. Antagonistic activities of virus particles modulated interferon production.
复制标题
病毒诱导干扰素。
DOI：
10.1089/jir.1982.2.511
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Marcus,PI
中科院分区：
文献类型：
--
作者：
Marcus,PI
细胞一般通过产生剂量(感染的复数)-反应(干扰素-产量)曲线来响应干扰素(干扰素)的病毒诱导剂，该曲线与干扰素产生者的比例与感染一个或多个颗粒的细胞的比例相对应的模型很好地吻合。这些被定义为干扰素诱导颗粒(IFP)。感染这些颗粒的细胞的干扰素产生能力在与第二种类型的病毒颗粒混合感染时被调节，第二种病毒颗粒具有抑制干扰素产生的能力。这些被称为干扰素诱导抑制颗粒(ISP)。在IFP和isp混合感染的细胞中，后者是显性表型。在某些系统中，当IFP在每个细胞中存在两个或更多颗粒时，isp活性由IFP表示。具有干扰素诱导拮抗活性的病毒颗粒的存在提供了一种机制来调节干扰素的产生，从而调节病毒感染的潜在结果。
Cells generally responded to viral inducers of interferon (IFN) by generating a dose (multiplicity of infection)-response (interferon-yield) curve which showed a good fit to a model in which the fraction of interferon-yielders corresponded to the fraction of cells infected with one or more particles. These were defined asinterferon-inducing particles(IFPs). The IFN-producing capacity of cells infected with these particles was modulated upon coinfection with a second type of virus particle, those with the capacity to suppress IFN production. These were termedinterferon induction-suppressing particles(ISPs). In cells coinfected with IFP and ISP the latter were dominant phenotypically. In some systems ISP activity was expressed by IFP when the latter were present at two or more particles per cell. The existence of virus particles with antagonistic activities for interferon induction provides a mechanism for regulating the production of IFN and hence the potential outcome of a virus infection.