Target of rapamycin (TOR) in nutrient signaling and growth control.
Target of rapamycin (TOR) in nutrient signaling and growth control.
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DOI：
10.1534/genetics.111.133363
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发表时间：
2011-12
期刊：
影响因子：
3.3
通讯作者：
Hall MN
中科院分区：
文献类型：
--
作者：
Loewith R;Hall MN
TOR（雷帕霉素靶标）是一种高度保守的蛋白激酶，在基础生物学和临床生物学中都很重要。在基础生物学中，TOR 是细胞生长和衰老的营养敏感的中央控制器。在临床生物学中，TOR 与许多疾病有关，并且是用于三个不同治疗领域的药物雷帕霉素的靶点。酿酒酵母在 TOR 的发现及其功能的阐明中发挥了重要作用。在这里，我们回顾了酿酒酵母中的 TOR 信号网络。
TOR (Target Of Rapamycin) is a highly conserved protein kinase that is important in both fundamental and clinical biology. In fundamental biology, TOR is a nutrient-sensitive, central controller of cell growth and aging. In clinical biology, TOR is implicated in many diseases and is the target of the drug rapamycin used in three different therapeutic areas. The yeast Saccharomyces cerevisiae has played a prominent role in both the discovery of TOR and the elucidation of its function. Here we review the TOR signaling network in S. cerevisiae.