Neuronal oxidative damage and dendritic degeneration following activation of CD14-dependent innate immune response in vivo.
Neuronal oxidative damage and dendritic degeneration following activation of CD14-dependent innate immune response in vivo.
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DOI：
10.1186/1742-2094-1-20
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发表时间：
2004-10-21
影响因子：
9.3
通讯作者：
Montine TJ
中科院分区：
文献类型：
--
作者：
Milatovic D;Zaja-Milatovic S;Montine KS;Shie FS;Montine TJ
先天免疫激活与神经退行性变之间的因果关系很难在复杂的动物模型和患者中得到证明。在这里，我们回顾了使用脂多糖脑室内注射通过 CD14 刺激直接先天免疫激活模型的研究结果。这些数据表明，大脑中 CD14 依赖性先天免疫激活导致神经元膜氧化损伤和树突变性的密切相关结果。在药理学相关浓度下，布洛芬和α-生育酚可以阻断这两种形式的神经元损伤，但不能阻断萘普生或γ-生育酚。该模型提供了一种方便的方法来确定有效药物及其适当的剂量范围，以保护神经元免受CD14激活的先天免疫介导的损伤，并且可以指导阿尔茨海默病等疾病的药物开发，这些疾病被认为部分源自CD14激活的先天免疫反应。
The cause-and-effect relationship between innate immune activation and neurodegeneration has been difficult to prove in complex animal models and patients. Here we review findings from a model of direct innate immune activation via CD14 stimulation using intracerebroventricular injection of lipopolysaccharide. These data show that CD14-dependent innate immune activation in cerebrum leads to the closely linked outcomes of neuronal membrane oxidative damage and dendritic degeneration. Both forms of neuronal damage could be blocked by ibuprofen and alpha-tocopherol, but not naproxen or gamma-tocopherol, at pharmacologically relevant concentrations. This model provides a convenient method to determine effective agents and their appropriate dose ranges for protecting neurons from CD14-activated innate immunity-mediated damage, and can guide drug development for diseases, such as Alzheimer disease, that are thought to derive in part from CD14-activated innate immune response.
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DOI：
10.1152/ajpregu.1998.275.6.r1812
发表时间：
1998-12-01
影响因子：
2.8
作者：
Dumont, I;Peri, KG;Chemtob, S
通讯作者：
Chemtob, S
影响因子：
6
作者：
Reich, EE;Markesbery, WR;Montine, TJ
通讯作者：
Montine, TJ
影响因子：
5.3
作者：
Nadeau, S;Rivest, S
通讯作者：
Rivest, S
影响因子：
4.4
作者：
Nadeau, S;Rivest, S
通讯作者：
Rivest, S
DOI：
10.1111/j.1749-6632.2002.tb04077.x
发表时间：
2002-01-01
期刊：
NITRIC OXIDE: NOVEL ACTIONS, DELETERIOUS EFFECTS AND CLINICAL POTENTIAL
影响因子：
--
作者：
Liu, B;Gao, HM;Hong, JS
通讯作者：
Hong, JS