Sequential Evolution of Cortical Activity and Effective Connectivity of Swallowing Using fMRI
Sequential Evolution of Cortical Activity and Effective Connectivity of Swallowing Using fMRI
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DOI：
10.1002/hbm.22597
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发表时间：
2014-12-01
影响因子：
4.8
通讯作者：
Lotze, Martin
中科院分区：
文献类型：
--
作者：
Mihai, Paul Glad;Otto, Mareile;Lotze, Martin
吞咽由初级运动和躯体感觉过程的层次序列组成。不同阶段的时间相互作用是复杂的，临床干扰频繁。有趣的是吞咽网络的时间相互作用。时间分辨率优化的功能磁共振成像用于描述吞咽表现部位的时间序列及其功能连通性。研究对象是16名年轻的健康志愿者，他们每次20次吞食2毫升水，功能成像的重复时间为514毫秒。在应用一般线性模型方法识别预先选择的感兴趣区的激活幅度后，使用重复测量方差分析(RmANOVA)来检测对侧化、时间和起始点的相关影响。此外，动态因果模型(DCM)被用来揭示输入进入模型的位置以及大脑皮层区域的连接方式。时间分析显示，从运动前皮质、辅助运动区(SMA)和双侧丘脑开始依次激活，然后是初级感觉运动皮质、后岛叶和小脑，最后在脑桥激活，不久之后就会消失。RmANOVA显示，激活最初偏侧化到左半球，随着时间的推移逐渐转移到右半球。群体随机效应DCM分析得出了一个最可能的模型，该模型包括SMA和M1S1的输入，双向连接，以及从M1S1到后岛的单向连接。Hum Brain Mapp 35：5962-5973,2014。(C)2014年威利期刊公司。
Swallowing consists of a hierarchical sequence of primary motor and somatosensory processes. The temporal interplay of different phases is complex and clinical disturbances frequent. Of interest was the temporal interaction of the swallowing network. Time resolution optimized functional magnetic resonance imaging was used to describe the temporal sequence of representation sites of swallowing and their functional connectivity. Sixteen young healthy volunteers were investigated who swallowed 2 ml of water 20 times per run with a repetition time for functional imaging of 514 ms. After applying the general linear model approach to identify activation magnitude in preselected regions of interest repeated measures analysis of variance (rmANOVA) was used to detect relevant effects on lateralization, time, and onset. Furthermore, dynamic causal modeling (DCM) was applied to uncover where the input enters the model and the way in which the cortical regions are connected. The temporal analysis revealed a successive activation starting at the premotor cortex, supplementary motor area (SMA), and bilateral thalamus, followed by the primary sensorimotor cortex, the posterior insula, and cerebellum and culminating with activation in the pons shortly before subsiding. The rmANOVA revealed that activation was lateralized initially to the left hemisphere and gradually moved to the right hemisphere over time. The group random effects DCM analysis resulted in a most likely model that consisted of inputs to SMA and M1S1, bidirectionally connected, and a one-way connection from M1S1 to the posterior insula. Hum Brain Mapp 35:5962-5973, 2014. (c) 2014 Wiley Periodicals, Inc.