Cyclophosphamide‐induced hemorrhagic cystitis in children with leukemia
Cyclophosphamide‐induced hemorrhagic cystitis in children with leukemia
复制标题
白血病儿童环磷酰胺所致出血性膀胱炎
DOI：
10.1002/1097-0142(197511)36:5
复制
发表时间：
1975
期刊：
影响因子：
6.2
通讯作者：
R. Aur
中科院分区：
文献类型：
--
作者：
H. J. Lawrence;J. Simone;R. Aur
回顾了314例急性淋巴细胞白血病（ALL）儿童的记录，以确定环磷酰胺诱导的出血性膀胱炎的频率，临床和实验室特征;促成因素;和预后。确定了25例记录良好的出血性膀胱炎病例。虽然大多数受影响的儿童患有轻度一过性疾病，但1名患者因膀胱出血而死亡。这些儿童接受的环磷酰胺剂量范围很广，与膀胱炎的严重程度无关。该并发症的发生率在性别、年龄或给药途径方面无显著差异。然而，膀胱炎在黑人儿童中的发生率是白色儿童的两倍多。25例中有19例发生在春季和夏季。受影响的儿童组在接受的总药物剂量、全身毒性发生率、平均尿比重或总生存率方面与匹配的对照组无显著差异。
The records of 314 children with acute lymphocytic leukemia (ALL) were reviewed to determine the frequency, clinical and laboratory features; contributing factors; and prognosis of cyclophosphamide‐induced hemorrhagic cystitis. Twenty‐five well‐documented cases of hemorrhagic cystitis were identified. While most of the affected children suffered a mild transient illness, 1 patient died as a result of bladder hemorrhage. The doses of cyclophosphamide received by these children ranged widely and did not correlate with the severity of the cystitis. The frequency of this complication did not differ significantly with sex, age or route of administration. However, cystitis was over twice as frequent in black children as in white. Nineteen of 25 cases occurred in the spring and summer months. The group of affected children did not differ significantly from a matched control group in terms of total drug dosage received, incidence of systemic toxicity, mean urine specific gravity, or overall survival.