Degradation of porous poly(anhydride-co-imide) microspheres and implications for controlled macromolecule delivery
Degradation of porous poly(anhydride-co-imide) microspheres and implications for controlled macromolecule delivery
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DOI：
10.1016/s0142-9612(97)00221-4
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发表时间：
1998-01-01
期刊：
影响因子：
14
通讯作者：
Langer, R
中科院分区：
文献类型：
--
作者：
Hanes, J;Chiba, M;Langer, R
研究了一种新型聚酸酐共聚物——聚酸酐-亚胺共聚物制备的多孔微球的降解性能。采用双乳液溶剂蒸发法制备了以牛血清白蛋白（BSA）为模型蛋白的聚[三甲基苯胺-酪氨酸-共癸二酸-共1,3-二（羧基苯氧基）丙烷]微球。水渗透和酸酐键裂解（聚合物降解）迅速发生(
The degradation properties of porous microspheres made using a new family of polyanhydride copolymers, the poly(anhydride-co-imides), were studied. Poly[trimellitylimido-L-tyrosine-co-sebacic acid-co-1,3-bis(carboxyphenoxy)propane] microspheres, with and without entrapped bovine serum albumin (BSA) as a model protein, were made using the double emulsion solvent evaporation process. Water penetration and anhydride bond cleavage (polymer degradation) occurred rapidly (