Neurophysiology - Good memories of bad events in infancy
Neurophysiology - Good memories of bad events in infancy
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DOI：
10.1038/35024156
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发表时间：
2000-09-07
期刊：
影响因子：
64.8
通讯作者：
Wilson, DA
中科院分区：
文献类型：
--
作者：
Sullivan, RM;Landers, M;Wilson, DA
如果一个无助的新生儿没有对其照顾者形成依恋，即使是一个虐待的人，他存活的机会也会减少，所以进化应该强烈支持婴儿的依恋，而不管照顾的质量如何。由于大脑中名为杏仁核的一部分对成年动物的获得性恐惧至关重要，我们调查了杏仁核功能的晚成熟是否会延缓获得性回避行为的发展。我们发现，暴露在与休克治疗相关的各种气味中的非常年轻的幼鼠学习对这种气味的接近反应，而年龄较大的幼鼠学习气味回避。我们发现，习得性气味回避行为的起源和发展与杏仁核在气味休克条件反射过程中神经反应的增强有关。
If a helpless newborn infant does not form an attachment to its care-giver, even an abusive one, its chances of survival diminish, so evolution should strongly favour attachment by the infant, regardless of the quality of care-giving. As a part of the brain called the amygdala is critical for learned fear in adult animals,,, we investigated whether the development of learned avoidance behaviour could be delayed by late maturation of amygdala function. We found that very young rat pups exposed to various odours associated with shock treatment learn an approach response to that odour, whereas older pups learn odour avoidance. We show that the origin and development of learned odour-avoidance behaviour is associated with enhanced neural responses in the amygdala during odour-shock conditioning.