Modeling extended twin family data I: description of the Cascade model.
Modeling extended twin family data I: description of the Cascade model.
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DOI：
10.1375/twin.12.1.8
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发表时间：
2009-02
期刊：
影响因子：
--
通讯作者：
Eaves LJ
中科院分区：
文献类型：
--
作者：
Keller MC;Medland SE;Duncan LE;Hatemi PK;Neale MC;Maes HH;Eaves LJ
经典的双生子设计使用单卵和双卵双生子之间的变异和协变数据来推断群体中表型变异的潜在遗传和环境原因。通过使用额外的相对类，如父母的数据，扩大双胞胎家庭设计更全面地描述了表型变异的原因。本文介绍了以前的扩展双胞胎家庭模型的扩展，级联模型，它使用双胞胎以及他们的兄弟姐妹，配偶，父母和子女的信息来区分两个遗传和六个环境来源的表型变异。Cascade还放宽了以前双胞胎大家庭设计中存在的关于交配和文化传播的假设。额外参数的估计和假设的放松可能是重要的，不仅因为它允许对表型变异的原因进行更细粒度的描述，而且更重要的是，因为它可以减少早期设计中存在的参数估计的偏差。
The classical twin design uses data on the variation of and covariation between monozygotic and dizygotic twins to infer underlying genetic and environmental causes of phenotypic variation in the population. By using data from additional relative classes, such as parents, extended twin family designs more comprehensively describe the causes of phenotypic variation. This article introduces an extension of previous extended twin family models, the Cascade model, which uses information on twins as well as their siblings, spouses, parents, and children to differentiate two genetic and six environmental sources of phenotypic variation. The Cascade also relaxes assumptions regarding mating and cultural transmission that existed in previous extended twin family designs. The estimation of additional parameters and relaxation of assumptions is potentially important, not only because it allows more fine-grained descriptions of the causes of phenotypic variation, but more importantly, because it can reduce the biases in parameter estimates that exist in earlier designs.
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影响因子：
22.4
作者：
JINKS, JL;FULKER, DW
通讯作者：
FULKER, DW
影响因子：
3.8
作者：
EAVES, L
通讯作者：
EAVES, L
影响因子：
0.9
作者：
Coventry, WL;Keller, MC
通讯作者：
Keller, MC
DOI：
10.1375/136905298320566465
发表时间：
1998-05-01
期刊：
Twin research : the official journal of the International Society for Twin Studies
影响因子：
--
作者：
Boomsma, D I
通讯作者：
Boomsma, D I
影响因子：
5.8
作者：
Danecek, Petr;Auton, Adam;Durbin, Richard
通讯作者：
Durbin, Richard