DOES PROTEIN-PHOSPHORYLATION PLAY A ROLE IN TRANSLATIONAL CONTROL BY EUKARYOTIC AMINOACYL-TRANSFER RNA-SYNTHETASES
DOES PROTEIN-PHOSPHORYLATION PLAY A ROLE IN TRANSLATIONAL CONTROL BY EUKARYOTIC AMINOACYL-TRANSFER RNA-SYNTHETASES
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DOI：
10.1016/0968-0004(90)90153-3
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发表时间：
1990-05-01
影响因子：
13.8
通讯作者：
CLEMENS, MJ
中科院分区：
文献类型：
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作者：
CLEMENS, MJ
氨基酰-tRNA还原酶长期以来被认为是所有生物体蛋白质合成途径中的关键酶。只有通过这些酶的介导，氨基酸才能被激活，通过形成氨酰-tRNA掺入生长的多肽链中。在为蛋白质合成提供直接前体方面如此明显的作用并不意味着我们期望这些酶具有额外的调节特性。然而，很明显，合成酶确实执行tRNA充电以外的功能（例如合成不寻常的核苷酸Ap 4A），最近的一些观察表明，氨酰-tRNA合成酶参与细胞适应氨基酸可用性变化。在这篇文章中，我的目的是提请注意这些潜在的重要功能，并讨论是否蛋白磷酸化，这两个合成酶
THE AMINOACYL-tRNA SYNTHETASES have long been identified as key enzymes in the pathway of protein synthesis in all living organisms. It is only through the mediation of these enzymes that amino acids can be activated for incorporation into growing polypeptide chains, via the formation of aminoacyl-tRNAs. Such an obvious role in providing the immediate precursors for protein synthesis does not lead us to expect additional regulatory properties of these enzymes. Nevertheless, it is clear that the synthetases do perform functions other than tRNA charging (such as the synthesis of the unusual nucleotide Ap4A for example) and a number of recent observations suggest that aminoacyl-tRNA synthetases are involved in cellular adaptation to changes in amino acid availability. In this article I aim to draw attention to such potentially important functions and to discuss whether protein phosphorylation, both of the synthetases