Utilization patterns of antidepressants between 1991 and 2011 in a population-based cohort of middle-aged and elderly
Utilization patterns of antidepressants between 1991 and 2011 in a population-based cohort of middle-aged and elderly
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DOI：
10.1016/j.eurpsy.2014.02.001
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发表时间：
2014-08-01
影响因子：
7.8
通讯作者：
Visser, L. E.
中科院分区：
文献类型：
--
作者：
Aarts, N.;Noordam, R.;Visser, L. E.
背景：在过去几十年中，抗抑郁药物使用有所增加的中老年患者中，使用模式可能值得关注。本研究的目的是调查老龄化人群中抗抑郁药物使用的患病率、发生率和持续时间。方法：从 1991 年 1 月 1 日起对基于人口的鹿特丹研究的所有参与者（年龄 > 45 岁）进行随访，直至死亡、失访或研究期结束（12 月 31 日） 2011）。根据药房记录，抗抑郁药物的配药分为三环类抗抑郁药（TCA）、选择性血清素再摄取抑制剂（SSRI）和其他抗抑郁药。计算了抗抑郁药使用的一年患病率、五年发生率和持续时间。结果：抗抑郁药使用年患病率从 1991 年的 3.9% 上升到 2011 年的 8.3%。 SSRI 使用量增加了 5.8 倍，而其他抗抑郁药的使用量增加了一倍，TCA 使用量随着时间的推移保持稳定。 1992 年至 2011 年间，所有抗抑郁药物的发病率从每 1000 人年 23.9 例下降至 14.2 例。首次治疗的持续时间随着时间的推移而增加。结论：尽管抗抑郁药物的使用率随着时间的推移而增加，但发病率却没有增加，这很可能是由于治疗持续时间较长和反复发作所致。 (C) 2014 年 Elsevier Masson SAS。版权所有。
Background: In middle-aged and older patients in whom antidepressant use increased in last decades, patterns of use might be of concern The objective of this study was to investigate the patterns of prevalence, incidence and duration of antidepressant use in an ageing population.Methods: All participants (aged > 45 years) from the population-based Rotterdam Study were followed from January 1st 1991 until death, loss to follow-up, or end of the study period (December 31st 2011). Antidepressant drug dispensing, based on pharmacy records, were subdivided into Tricyclic Antidepressants (TCAs), Selective Serotonin Reuptake Inhibitors (SSRIs) and other antidepressants. One-year prevalence, 5-year incidence and duration of antidepressant use were calculated.Results: Yearly prevalence of antidepressant use increased from 3.9% in 1991 to 8.3% of the population in 2011. The increase in SSRI use was 5.8-fold, whereas use of other antidepressants doubled and TCA use remained stable over time. Incidence of all antidepressants decreased from 23.9 to 14.2 per 1000 person-years between 1992 and 2011. The duration of a first treatment episode increased over time.Conclusion: Despite the prevalence of antidepressant use increased over time, incidence did not, which is most likely explained by a longer treatment duration and recurrent episodes. (C) 2014 Elsevier Masson SAS. All rights reserved.