A novel murine model for assessing fetal and birth outcomes following transgestational maternal malaria infection.
A novel murine model for assessing fetal and birth outcomes following transgestational maternal malaria infection.
复制标题
一种用于评估妊娠期母体疟疾感染后胎儿和出生结局的新型小鼠模型。
DOI：
10.1038/s41598-019-55588-8
复制
发表时间：
2019
影响因子：
4.6
通讯作者：
Moore,JulieM
中科院分区：
文献类型：
--
作者：
MorffySmith,CatherineD;Russ,BrittanyN;Andrew,AlicerK;Cooper,CaitlinA;Moore,JulieM
Plasmodium falciparuminfection during pregnancy is a major cause of severe maternal illness and neonatal mortality. Mouse models are important for the study of gestational malaria pathogenesis. When infected withPlasmodium chabaudi chabaudiAS in early gestation, several inbred mouse strains abort at midgestation. We report here that outbred Swiss Webster mice infected withP.chabaudi chabaudiAS in early gestation carry their pregnancies to term despite high parasite burden and malarial hemozoin accumulation in the placenta at midgestation, with the latter associated with induction of heme oxygenase 1 expression. Infection yields reduced fetal weight and viability at term and a reduction in pup number at weaning, but does not influence postnatal growth prior to weaning. This novel model allows for the exploration of malaria infection throughout pregnancy, modeling chronic infections observed in pregnant women prior to the birth of underweight infants and enabling the production of progeny exposed to malariain utero, which is critical for understanding the postnatal repercussions of gestational malaria. The use of outbred mice allows for the exploration of gestational malaria in a genetically diverse model system, better recapitulating the diversity of infection responses observed in human populations.
