HBZ, a new important player in the mystery of adult T-cell leukemia
HBZ, a new important player in the mystery of adult T-cell leukemia
复制标题
DOI：
10.1182/blood-2006-03-007732
复制
发表时间：
2006-12-15
期刊：
影响因子：
20.3
通讯作者：
Devaux, Christian
中科院分区：
文献类型：
--
作者：
Mesnard, Jean-Michel;Barbeau, Benoit;Devaux, Christian
成人T细胞白血病（ATL）于1977年首次被描述。ATL和人类T细胞白血病病毒1型（HTLV-1）之间的联系在20世纪80年代初就已明确确立。多年来，HTLV-1诱导的细胞功能障碍的许多方面已经澄清。然而，ATL发生背后的详细机制仍然没有解决。目前，我们仍然无法解释超过50%的ATL细胞中病毒Tax蛋白（被认为在T细胞转化中起核心作用）的缺失。一种新的HTLV-1 HBZ蛋白，编码的负链，其特征在于由我们的小组，目前是深入研究工作的主题，以确定其在病毒复制和/或病理生理学的功能。最近，4项研究报道了不同HBZ亚型的存在，并研究了它们在ATL细胞或动物模型中的功能。一份报告表明，HBZ基因可能具有双峰功能（在mRNA和蛋白质水平），这可能代表了一种未表征的策略来调节病毒复制和感染T细胞的增殖。
Adult T-cell leukemia (ATL) was first described in 1977. A link between ATL and human T-cell leukemia virus type 1 (HTLV-1) was clearly established in the early 1980s. Over the years, many aspects of HTLV-1-induced cellular dysfunctions have been clarified. However, the detailed mechanism behind ATL occurrence remains unsolved. Presently, we are still unable to explain the absence of viral Tax protein (thought to play a central role in T-cell transformation) in more than 50% of ATL cells. A novel HTLV-1 HBZ protein, encoded on the negative strand, was characterized by our group and is currently the subject of intensive research efforts to determine its function in viral replication and/or pathophysiology. Recently, 4 studies reported on the existence of different HBZ isoforms and have investigated on their function in both ATL cells or animal models. One report suggests that the HBZ gene might have a bimodal function (at the mRNA and protein levels), which could represent an uncharacterized strategy to regulate viral replication and proliferation of infected T cells.