Size-scaling effects for microparticles and cells manipulated by optoelectronic tweezers
Size-scaling effects for microparticles and cells manipulated by optoelectronic tweezers
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DOI：
10.1364/ol.44.004171
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发表时间：
2019-09-01
期刊：
影响因子：
3.6
通讯作者：
Neale, Steven L.
中科院分区：
文献类型：
--
作者：
Zhang, Shuailong;Li, Weizhen;Neale, Steven L.
在这项工作中，我们研究了使用光电子镊子（OET）来操纵比通常使用标准光镊定位的物体更大的物体。我们研究了不同大小的聚苯乙烯微珠和MCF-7乳腺癌细胞与光诱导介电泳（DEP）可以产生的力。发现施加在珠/细胞上的DEP力不随珠/细胞的体积线性增加，主要是因为OET底板上方的电场分布不均匀。虽然这种尺寸缩放工作的重点是微粒和细胞，我们建议，在这项研究中阐明的物理机制将是有见地的其他微物体，生物样品和微执行器进行OET操作。由The Optical Society根据Creative Commons Attribution 4.0 License条款发布。
In this work, we investigated the use of optoelectronic tweezers (OET) to manipulate objects that are larger than those commonly positioned with standard optical tweezers. We studied the forces that could be produced on differently sized polystyrene microbeads and MCF-7 breast cancer cells with light-induced dielectrophoresis (DEP). It was found that the DEP force imposed on the bead/cell did not increase linearly with the volume of the bead/cell, primarily because of the non-uniform distribution of the electric field above the OET bottom plate. Although this size-scaling work focuses on microparticles and cells, we propose that the physical mechanism elucidated in this research will be insightful for other micro-objects, biological samples, and micro-actuators undergoing OET manipulation. Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License.