Cerebral activation patterns during working memory performance in multiple sclerosis using fMRI
Cerebral activation patterns during working memory performance in multiple sclerosis using fMRI
复制标题
DOI：
10.1080/138033990513609
复制
发表时间：
2005-01-01
影响因子：
2.2
通讯作者：
Deluca, J
中科院分区：
文献类型：
--
作者：
Chiaravalloti, ND;Hillary, FG;Deluca, J
工作记忆缺陷在多发性硬化症（MS）中很常见，并已在许多研究中被确定为行为。尽管最近的进展，功能性磁共振成像（fMRI），很少有发表的研究已经研究了大脑激活与MS的工作记忆功能障碍。本研究探讨了大脑激活模式在个人的工作记忆任务的表现与临床明确的MS，相比，健康对照组（HC）。使用1.5特斯拉GE扫描仪在改良的起搏听觉序列加法测试（mPA-SAT）期间进行fMRI。参与者为6名神经心理学测试证明存在工作记忆障碍的MS患者，5名无工作记忆障碍的MS患者，5个HC组在人口统计学上相当。使用统计参数映射（SPM 99）软件分析数据，具有严格的显著性水平（α = 8）。MS组和HC组都能够执行任务，在正确回答的数量方面具有可比性。HC和MS未受损组中的激活模式在相似的脑区中观察到，与健康样本中发表的观察结果一致。也就是说，激活是偏左的，主要涉及额叶区域。与此相反，MS受损组表现出更大的右额叶和右顶叶激活，与HC组相比。因此，MS中的工作记忆功能障碍似乎与大脑激活模式的改变有关，这些模式与认知障碍的存在有关，而不仅仅是MS的功能。
Working memory deficits are common in Multiple Sclerosis (MS) and have been identified behaviorally in numerous studies. Despite recent advance in functional magnetic resonance imaging (fMRI), few published studies have examined cerebral activations associated with working memory dysfunction in MS. The present study examines brain activation patterns during performance of a working memory task in individuals with clinically definite MS, compared to healthy controls (HC). fMRI was performed using a 1.5 Tesla GE scanner during a modified Paced Auditory Serial Addition Test (mPA-SAT). Participants were 6 individuals with MS with working memory impairment as evidenced on neuropsychological testing, 5 individuals with MS without working memory impairment, and 5 HC Groups were demographically equivalent. Data were analyzed using Statistical Parametric Mapping (SPM99) software, with a stringent significance level (alpha = 8). Both MS groups and the HC group were able to perform the task, with comparable performance in terms of numbers of correct responses. Activation patterns within the HC and MS not-impaired groups were noted in similar brain regions, consistent with published observations in healthy samples. That is, activations were lateralized to the left hemisphere, involving predominantly frontal regions. In contrast, the MS impaired group showed greater right frontal and right parietal lobe activation, when compared with the HC group. Thus, it appears that working memory dysfunction in MS is associated with altered patterns of cerebral activation that are related to the presence of cognitive impairment, and not solely a function of MS.