Linking mind and brain in the study of mental illnesses: A project for a scientific psychopathology
Linking mind and brain in the study of mental illnesses: A project for a scientific psychopathology
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DOI：
10.1126/science.275.5306.1586
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发表时间：
1997-03-14
期刊：
影响因子：
56.9
通讯作者：
Andreasen, NC
中科院分区：
文献类型：
--
作者：
Andreasen, NC
近年来，在认知神经科学概念和技术发展的支持下，精神疾病的大脑研究取得了实质性进展。精神分裂症和抑郁症等疾病的基于大脑的认知模型已经通过多种技术进行了测试，包括病变方法、纤维束追踪、神经影像学、动物建模、单细胞记录、电生理学、神经心理学和实验认知心理学。一幅相对复杂的图景正在出现，它将精神疾病概念化为大脑中出现的精神障碍。使用多种神经科学技术的聚合数据表明，精神疾病的神经机制可以理解为特定神经回路的功能障碍，并且其功能和功能障碍可以受到多种认知和药理学因素的影响或改变。
Brain research on mental illnesses has made substantial advances in recent years, supported by conceptual and technological developments in cognitive neuroscience. Brain-based cognitive models of illnesses such as schizophrenia and depression have been tested with a variety of techniques, including the lesion method, tract tracing, neuroimaging, animal modeling, single-cell recording, electrophysiology, neuropsychology, and experimental cognitive psychology. A relatively sophisticated picture is emerging that conceptualizes mental illnesses as disorders of mind arising in the brain. Convergent data using multiple neuroscience techniques indicate that the neural mechanisms of mental illnesses can be understood as dysfunctions in specific neural circuits and that their functions and dysfunctions can be influenced or altered by a variety of cognitive and pharmacological factors.