Natural history of functional gastrointestinal disorders: A 12-year longitudinal population-based study
Natural history of functional gastrointestinal disorders: A 12-year longitudinal population-based study
复制标题
DOI：
10.1053/j.gastro.2007.06.010
复制
发表时间：
2007-09-01
期刊：
影响因子：
29.4
通讯作者：
Talley, Nicholas J.
中科院分区：
文献类型：
--
作者：
Halder, Smita L. S.;Locke, G. Richard, III;Talley, Nicholas J.
背景与目标：功能性胃肠道疾病 (FGID) 在社区中很常见。由于缺乏基于人群的前瞻性研究以及表型的不明确性质，FGID 的自然史尚不清楚。我们试图报告美国人群中 FGID 的自然史。方法：这项前瞻性队列研究使用了明尼苏达州奥姆斯特德县居民在 1988 年至 2003 年间平均 12 年期间（n = 1365）随机样本的多项经过验证的调查数据。该调查测量了过去一年中经历的胃肠道症状。每个受试者至少接受 2 次调查。计算了个体 FGID 的点患病率、发病率、消失率以及转变概率。结果：在初次调查和最终调查之间，肠易激综合征（分别为 8.3% 和 11.4%）和功能性消化不良（分别为 1.9% 和 3.3%）的点患病率（每 100 名居民）保持稳定。研究的每种疾病的发病率均大于消失率，但不同亚组的转移概率有所不同。在基线时有症状的人中，大约 20% 的人有相同的症状，40% 的人没有症状，40% 的人在随访时有不同的症状。结论：虽然 FGID 的患病率随着时间的推移保持稳定，但症状状态的变化很高。许多症状消失是由于受试者症状改变而不是总体症状消失。不同 FGID 之间的这种转变表明了共同的发病机制。
Background& Aims: Functional gastrointestinal disorders (FGID) are common in the community. The natural history of FGID is unknown because of a lack of prospective population-based studies and the indistinct nature of the phenotype. We sought to report the natural history of FGID in a US population. Methods: This prospective cohort study used data from multiple validated surveys of random samples of Olmsted County, MN, residents over a mean of a 12-year period between 1988 and 2003 (n = 1365). The surveys measured gastrointestinal symptoms experienced during the past year. Each subject received a minimum of 2 surveys. Point prevalence, onset, and disappearance rates and transition probabilities were calculated for individual FGlDs. Results: Between the initial and final surveys, the point prevalences (per 100 residents) were stable for irritable bowel syndrome (8.3% and 11.4%, respectively) and functional dyspepsia (1.9% and 3.3%, respectively). The onset of each of the disorders studied was greater than the disappearance rate, but the transition probabilities varied across the different subgroups. Among people with symptoms at baseline, approximately 20% had the same symptoms, 40% had no symptoms, and 40% had different symptoms at follow-up. Conclusions: Although the prevalence of the FGID was stable over time, the turnover in symptom status was high. Many episodes of symptom disappearance were due to subjects changing symptoms rather than total symptom resolution. This transition between different FGIDs suggests a common etiopathogenesis.