Mandibular prognathism in Japanese families ascertained through orthognathically treated patients
Mandibular prognathism in Japanese families ascertained through orthognathically treated patients
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DOI：
10.1016/j.ajodo.2004.09.018
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发表时间：
2005-10-01
影响因子：
3
通讯作者：
Ohyama, K
中科院分区：
文献类型：
--
作者：
Watanabe, M;Suda, N;Ohyama, K
简介：严重下颌前突的患者经常需要进行正颌手术来纠正骨骼不协调。下颌前突的病因可能有遗传和环境因素，但这些因素的确切作用尚不清楚。方法：为明确遗传因素对下颌前突的影响，对105名计划或已接受正颌手术的严重骨性Ⅲ类下颌前突受试者进行问卷调查。该问卷评估了每个受试者家族 3 代人的下颌前突情况。所有答案都在仔细的采访中得到证实，其中包括“上颌骨不足”和“下颌骨过多”的区分。这是第一个针对正颌治疗患者下颌前突的 3 代家族研究。结果：先证者的平均 ANB、SNA 和 SNB 角度分别为 -3.7 度、80.9 度和 84.6 度。共检查了1480名家庭成员，11.2%有下颌前突。男性受到的影响略大于女性； 68.6%的家庭除先证者外至少有1名下颌前突的成员。一级亲属的患病率是二级亲属的两倍多（分别为117.5%和7.6%）。先证者的父亲和母亲之间的发生率没有差异，兄弟姐妹的患病率高达25.0%。 Falconer 一级亲属的遗传力经计算为 84.3%。结论：在接受正颌治疗的骨性 III 类患者的家族中，下颌前突的发生率很高，这表明遗传因素具有深远的影响。
Introduction: Patients with severe mandibular prognathism frequently require orthognathic surgery to correct skeletal disharmony. Genetic and environmental factors are suggested in the etiology of mandibular prognathism, but the precise contribution of these factors is unknown. Methods: To clarify the impact of genetic factors on mandibular prognathism, we gave a questionnaire to 105 subjects with severe skeletal Class III mandibular prognathism who planned to undergo or had undergone orthognathic surgery. The questionnaire assessed mandibular prognathism in 3 generations of each subject's family. All answers were confirmed in a careful interview that included differentiation of "maxillary deficiency" and "mandibular excess." This is the first 3-generation family study of mandibular prognathism in orthognathically treated patients. Results: The average ANB, SNA, and SNB angles in the probands were -3.7 degrees, 80.9 degrees, and 84.6 degrees, respectively. A total of 1480 family members were examined, and 11.2% had mandibular prognathism. Men were slightly more affected than women; 68.6% of families had at least 1 member other than the proband with mandibular prognathism. The affected ratio of first-degree relatives was more than twice that of second-degree relatives (117.5% and 7.6%, respectively). There was no difference in the occurrence between fathers and mothers of probands, and siblings showed a high affected ratio of 25.0%. Falconer's heritability was calculated as 84.3% in first-degree relatives. Conclusions: A high occurrence of mandibular prognathism was seen in families of orthognathically treated skeletal Class III patients, suggesting a profound genetic influence.