Increased levels of interleukin-18 in bronchoalveolar lavage fluid of patients with idiopathic nonspecific interstitial pneumonia
Increased levels of interleukin-18 in bronchoalveolar lavage fluid of patients with idiopathic nonspecific interstitial pneumonia
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DOI：
10.1159/000083399
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发表时间：
2005-01-01
期刊：
影响因子：
3.7
通讯作者：
Kohno, S
中科院分区：
文献类型：
--
作者：
Ishii, H;Mukae, H;Kohno, S
背景：白细胞介素18(IL-18)是一种促炎细胞因子，可诱导干扰素-γ(IFN-γ)产生，在T辅助细胞1应答中发挥重要作用。在特发性间质性肺炎(IIP)中，非特异性间质性肺炎(NSIP)的支气管肺泡灌洗液(BAL)中淋巴细胞数量明显高于普通型间质性肺炎(UIP)。然而，它们在发病机制上的差异尚不清楚。目的：探讨IL-18在特发性尿路感染(UIP)和特发性非尿路感染(NSIP)中的作用。方法：检测22例IIP患者(UIP组12例，NSIP组10例)和9例健康体检者血清和BAL液中IL-18和干扰素-γ的水平。结果：NSIP组BALF中淋巴细胞比例明显高于UIP组和正常对照组。所有受试者血清IL-18水平均无显著差异，但NSIP患者BALF中IL-18水平显著高于UIP患者(p<；0.005)和正常人(p<；0.005)。在所有受试者中，BALF中IL-18水平与血清IL-18水平及BALF中淋巴细胞比例显著相关。所有受试者血清干扰素-γ水平均低于敏感度，但与BALF中淋巴细胞比例呈显著负相关。结论：特发性NSIP和部分特发性UIP患者BALF中淋巴细胞增多可能与IL-18水平升高有关。版权所有(C)2005 S.Karger AG，巴塞尔。
Background: Interleukin-18 (IL-18) is a proinflammatory cytokine that can induce interferon-gamma (IFN-gamma), and it plays an important role in T- helper 1 responses. Among idiopathic interstitial pneumonia (IIP), nonspecific interstitial pneumonia (NSIP) has an increased number of lymphocytes in bronchoalveolar lavage (BAL) fluid compared with usual interstitial pneumonia (UIP). However, the difference in their pathogenesis is unclear. Objective: The present study aims to investigate the roles of IL-18 in patients with idiopathic UIP and idiopathic NSIP. Methods: We measured the serum and BAL fluid (BALF) levels of IL-18 and IFN-gamma in 22 patients with IIP ( 12 with UIP, 10 with NSIP) and 9 healthy volunteers. Results: Lymphocyte proportions in BALF were significantly higher in NSIP than in UIP and healthy subjects. No significant differences were observed in the serum IL-18 levels of all subjects, while the BALF levels of IL-18 in patients with NSIP were significantly higher than in patients with UIP ( p < 0.005) and in healthy subjects ( p < 0.005). Among all subjects, the levels of IL- 18 in BALF correlated significantly with those in serum and the lymphocyte proportions in BALF. The serum IFN-gamma levels of all subjects were below sensitivity, but there was significant reverse correlation between the levels of IFN-gamma and the lymphocyte proportions in BALF. Conclusion: The lymphocytosis in BALF of patients with idiopathic NSIP and a part of idiopathic UIP might be associated with the high levels of IL-18. Copyright (C) 2005 S. Karger AG, Basel.