UNILATERAL INHIBITION OF AUDIOGENIC SEIZURES AND PREYER REFLEXES
UNILATERAL INHIBITION OF AUDIOGENIC SEIZURES AND PREYER REFLEXES
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DOI：
10.1038/240481a0
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发表时间：
1972-01-01
期刊：
影响因子：
64.8
通讯作者：
WILLOTT, JF
中科院分区：
文献类型：
--
作者：
HENRY, KR;WILLOTT, JF
在神经发育的关键时期，将小鼠暴露在大声的声刺激下 30 秒将会改变动物，因此几天或几周后的后续暴露会导致抽搐，通常会导致死亡1。第一次（启动）暴露的影响需要几天时间才能明显显现出来。 Fuller 和 Collins2 已经表明，只要手术持续进行，启动后每 6-12 小时重新暴露于大声的声音就会延迟惊厥的发生，并且这种效应可以在神经系统内偏向化 3。本文通过使用改进的技术形式扩展了他们的发现，该技术抑制了充分发展的启动效应，并证明声抑制将声惊吓反应的阈值提高了 21 dB，并且这种效应可以侧化到听觉系统的单侧。
EXPOSING a mouse to a loud acoustic stimulus for 30 s during a critical period of neural development will alter the animal so that a subsequent exposure days or weeks later results in convulsions which often terminate in death1. The effects of this first (priming) exposure require several days before they are overtly manifest. Fuller and Collins2have shown that re-exposure to loud sounds every 6–12 h after priming delays the onset of convulsibility for as long as the procedure is continued, and that this effect can be lateralized within the nervous system3. This paper extends their findings by the use of a modified form of their technique which inhibited the fully developed effects of priming, and demonstrates that acoustic inhibition increases the threshold to the acoustic startle response by 21 dB, and that this effect can be lateralized to a single side of the auditory system.