Alterations of the retinoblastoma gene in clinically localized, stage B prostate adenocarcinomas
Alterations of the retinoblastoma gene in clinically localized, stage B prostate adenocarcinomas
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DOI：
10.1016/s0046-8177(96)90134-3
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发表时间：
1996-01-01
期刊：
影响因子：
3.3
通讯作者：
Wieczorek, R
中科院分区：
文献类型：
--
作者：
Ittmann, MM;Wieczorek, R
视网膜母细胞瘤（Rb）肿瘤抑制基因及其编码蛋白的改变已在多种恶性肿瘤中检测到。作者对26例临床定位的B期前列腺癌进行了13 q14（包括Rb位点）杂合性缺失（洛）、Rb基因重排或部分缺失以及Rb蛋白水平改变的定量免疫组化研究。Rb位点的洛缺失发生在35%的标本中。在显示洛缺失的标本中，33%的肿瘤细胞中Rb蛋白定量免疫组化检测也显示减少或缺失。相反，没有洛缺失的标本均无Rb蛋白缺失。因此，洛缺失与Rb蛋白的缺失相关。作者的结论是Rb肿瘤抑制基因的改变发生在B期前列腺癌的一个重要部分。版权所有（C）1996由W.B.桑德斯公司
Alterations of the retinoblastoma (Rb) tumor suppressor gene and its encoded protein have been detected in a variety of malignant neoplasms. The authors have evaluated a series of 26 clinically localized stage B prostate adenocarcinomas for loss of heterozygosity (LOH) at 13q14 (including the Rb locus), rearrangements or partial deletions of the Rb gene, and alterations of Rb protein level by quantitative immunohistochemistry. LOH at the Rb locus occurred in 35% of the informative specimens. Of the specimens that showed LOH, 33% also had decreased or absent Rb protein in tumor cells by quantitative immunohistochemistry. In contrast, none of the specimens without LOH showed loss of Rb protein. Thus, LOH is correlated with loss of Rb protein. The authors conclude that alterations of the Rb tumor suppressor gene occur in a significant fraction of stage B prostate adenocarcinomas. Copyright (C) 1996 by W.B. Saunders Company