General anesthetic actions on GABA(A) receptors.

General anesthetic actions on GABA(A) receptors.
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DOI:
10.2174/157015910790909502
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发表时间:
2010-03
影响因子:
5.3
通讯作者:
Jenkins A
Jenkins A
中科院分区:
医学2区
文献类型:
--
作者:
Garcia PS;Kolesky SE;Jenkins A

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全身麻醉药物与神经系统中的许多受体相互作用,但只有少数这些相互作用对产生麻醉至关重要。在过去的20年里,神经药理学家已经揭示了全麻最重要的靶点之一是GABAA受体。在这篇综述中,我们将讨论已知的麻醉剂- GABAA受体相互作用。
General anesthetic drugs interact with many receptors in the nervous system, but only a handful of these interactions are critical for producing anesthesia. Over the last 20 years, neuropharmacologists have revealed that one of the most important target sites for general anesthetics is the GABAA receptor. In this review we will discuss what is known about anesthetic – GABAA receptor interactions.
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