Role of aldosterone in the activation of primary mice hepatic stellate cell and liver fibrosis via NLRP3 inflammasome
Role of aldosterone in the activation of primary mice hepatic stellate cell and liver fibrosis via NLRP3 inflammasome
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醛固酮通过NLRP3炎症小体激活原代小鼠肝星状细胞和肝纤维化的作用
DOI：
10.1111/jgh.14961
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发表时间：
2020-01-14
影响因子：
4.1
通讯作者：
Li, Xu
中科院分区：
文献类型：
--
作者：
Li, Yang;Zhang, Yijie;Li, Xu
新的证据表明，醛固酮（aldosterone，aldo）和NLRP 3炎性体是HSC活化和肝纤维化的重要因素。然而，Aldo和NLRP 3炎性小体在HSC活化和肝纤维化中的相互作用在很大程度上仍然未知。本研究旨在探讨Aldo与NLRP 3炎性小体在肝纤维化中的关系。
Emerging evidence suggests aldosterone (aldo) and NLRP3 inflammasome are important factors for HSC activation and liver fibrosis. However, the interaction between aldo and NLRP3 inflammasome in HSC activation and liver fibrosis remains largely unknown. The aim of this study is to investigate the relationship between aldo and NLRP3 inflammasome in liver fibrosis.