FACTORS AFFECTING INTERINDIVIDUAL VARIATION IN HUMAN PLASMA CHOLINESTERASE ACTIVITY - BODY-WEIGHT, HEIGHT, SEX, GENETIC-POLYMORPHISM AND AGE
FACTORS AFFECTING INTERINDIVIDUAL VARIATION IN HUMAN PLASMA CHOLINESTERASE ACTIVITY - BODY-WEIGHT, HEIGHT, SEX, GENETIC-POLYMORPHISM AND AGE
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DOI：
10.1007/bf01061095
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发表时间：
1993-01-01
影响因子：
4
通讯作者：
BROCK, V
中科院分区：
文献类型：
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作者：
BROCK, A;BROCK, V
采用多元回归模型研究了体重、身高、年龄和性别对650名ChE-1表型U（基因型ChE（u）ChE（u）或ChE（u）ChE（s））或UA（基因型ChE（u）ChE（a））男性和437名女性血浆胆碱酯酶活性（ChE）的影响。胆碱酯酶不受年龄的影响（p > 0.01），但与其它肝合成酶一样，受体重和身高的影响很大（p < 0.001）。在对数标度中，ChE遵循具有随机分布残差的线性模型（R = 0.535，p < 0.001），InChE = 3.286 - 0.308 x ChE-1表型-0.104 x性别+0.00765 x体重-0.00723 x身高（U = 1，UA = 2;男性= 1，女性= 2; kg; cm）。基于体重指数（BMI =体重除以身高的平方，kg/m2）的简化模型，InCHE = 2.016 - 0.308 x ChE-1表型-0.091 x性别+0.0230 x BMI，显示出相同的拟合优度（R = 0.533）。在一个非对数尺度的多元回归模型未能适合高胆碱酯酶活性的情况下。一个“标准化”的血浆胆碱酯酶的模型，其中的影响，胆碱酯酶-1表型，性别，体重和身高被淘汰，建议比较胆碱酯酶在不匹配的人群中使用这种酶的活性作为生物标志物时，在环境或职业医学。
The influence of body weight, height, age and sex on plasma cholinesterase activity (ChE) in 650 males and 437 females with ChE-1 phenotype U (genotype ChE(u)ChE(u) or ChE(u)ChE(s)) or UA (genotype ChE(u)ChE(a)) was studied in a multiple regression model. ChE was not influenced by age (p > 0.01), but, like other liver synthesized plasma enzymes, highly (p < 0.001) influenced by body weight and height. In a logarithmic scale ChE followed a linear model (R = 0.535, p < 0.001) with randomly distributed residuals, lnChE = 3.286 - 0.308 x ChE-1 phenotype - 0.104 x sex + 0.00765 x weight - 0.00723 x height (U = 1, UA = 2; male = 1, female = 2; kg; cm). A simplified model based on body-mass index (BMI = weight divided by squared height, kg/m2), InCHE = 2.016 - 0.308 x ChE-1 phenotype - 0.091 x sex + 0.0230 x BMI, showed the same goodness-of-fit (R = 0.533). In a non-logarithmic scale both multiple regression models failed to fit cases with high ChE activity. A model for a 'standardized' plasma ChE in which the effects of ChE-1 phenotype, sex, body weight and height are eliminated, is proposed to compare ChE in unmatched population groups when using this enzyme activity as a biomarker in environmental or occupational medicine.