DNA enzymes
DNA enzymes
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DOI：
10.1038/nbt0597-427
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发表时间：
1997-05-01
影响因子：
46.9
通讯作者：
Breaker, RR
中科院分区：
文献类型：
--
作者：
Breaker, RR
生物催化由蛋白质组成的酶主导，但已知几种不同类型的催化RNA可以促进细胞代谢所必需的化学转化。生物催化作用是否仅限于这两种生物聚合物，或者DNA在自然界中是否也能够发挥酶的作用？迄今为止，还没有发现天然来源的DNA酶，但是，越来越多的具有催化作用的DNA正在细胞外产生，这些DNA具有与核酶相似的特性。对DNA结构形成潜力的评估得出的结论是，DNA可能具有相当大的潜在酶功能。
Biological catalysis is dominated by enzymes that are made of protein, but several distinct classes of catalytic RNAs are known to promote chemical transformations that are fundamental to cellular metabolism. Is biological catalysis limited only to these two biopolymers, or is DNA also capable of functioning as an enzyme in nature? To date, no DNA enzymes of natural origin have been found. However, an increasing number of catalytic DNAs, with characteristics that are similar to those of ribozymes, are being produced outside the confines of the cell. An assessment of the potential for structure formation by DNA leads to the conclusion that DNA might have considerable latent potential for enzymatic function.