Genome-wide association study of hematological and biochemical traits in a Japanese population
Genome-wide association study of hematological and biochemical traits in a Japanese population
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DOI：
10.1038/ng.531
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发表时间：
2010-03-01
期刊：
影响因子：
30.8
通讯作者：
Kamatani, Naoyuki
中科院分区：
文献类型：
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作者：
Kamatani, Yoichiro;Matsuda, Koichi;Kamatani, Naoyuki
我们报告了来自相似的14,700名日本人的血液学和生化特征的全基因组关联研究。在全基因组显著水平(P<；5×10(-8))，我们确定了8个血液学性状的60个关联和12个生化性状的29个关联。在这项研究中，46个关联是新的，43个重复先前的报告。我们将这些相关的基因座与欧洲人群中类似的GWA型基因座进行了比较。在日本人群中，当次要等位基因频率为>；10%时，在欧洲人群中，先前报道的34个血液学基因座中的32个(94.1%)和31个(91.2%)被复制，P值分别小于0.05和0.01，42个欧洲生化基因座中的31个(73.8%)和27个(64.3%)被复制。
We report genome-wide association studies for hematological and biochemical traits from similar to 14,700 Japanese individuals. We identified 60 associations for 8 hematological traits and 29 associations for 12 biochemical traits at genome-wide significance levels (P < 5 x 10(-8)). Of these, 46 associations were new to this study and 43 replicated previous reports. We compared these associated loci with those reported in similar GWAS in European populations. When the minor allele frequency was >10% in the Japanese population, 32 (94.1%) and 31 (91.2%) of the 34 hematological loci previously reported to be associated in a European population were replicated with P-values less than 0.05 and 0.01, respectively, and 31 (73.8%) and 27 (64.3%) of the 42 European biochemical loci were replicated.