Relationship between trabecular bone structure and articular cartilage morphology and relaxation times in early OA of the knee joint using parallel MRI at 3 T
Relationship between trabecular bone structure and articular cartilage morphology and relaxation times in early OA of the knee joint using parallel MRI at 3 T
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DOI：
10.1016/j.joca.2008.02.018
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发表时间：
2008-10-01
影响因子：
7
通讯作者：
Majumdar, Sharmila
中科院分区：
文献类型：
--
作者：
Bolbos, R. I.;Zuo, Jin;Majumdar, Sharmila
目的：方法：采用3 T磁共振扫描仪和8通道膝关节相控阵线圈，对16名健康对照者和16名轻度骨关节炎（OA）患者在3 T磁共振成像（MRI）并行成像条件下进行骨小梁结构与软骨参数的相关性研究。采集轴向3D GeneRalized自动校准部分并行采集（GRAPPA）相位循环快速成像稳态采集（FIFSTA-c）图像，以量化骨小梁结构。为了评估软骨形态（厚度、体积），采集矢状面高分辨率3D扰相梯度回波（SPGR）图像。在实验对象的一个子集中。结果：骨参数的测量重复性好，变异系数（CV）从骨小梁数目（app. Tb-N）的1.8%到骨小梁分离（app. Tb.Sp）的5.5%。对照组和CA组之间的显着差异，发现骨体积分数，骨体积占总体积（约BV/TV）和约Tb。Sp在所有的隔间。与对照组相比，CA患者股骨T1 rho和T2值显著增加，但胫骨未增加。股骨内侧髁（MFC）和胫骨外侧（LT）的T_2与app. BV/TV、app. Tb.N和app. Tb.Sp均呈负相关，而胫骨内侧（MT）的T_1 rho与app. BV/TV呈负相关（R-2 =-0.49，P < 0.05）和近似Tb.N（R-2 =-0.42，P < 0.05）。骨小梁参数与软骨厚度和标准化体积之间存在显著相关性，主要在LT、胫骨（T）和股骨（F）。结论：在CA的早期阶段，患者的骨结构参数总体下降，软骨参数（T1 rho，T2）增加。骨小梁结构与关节软骨参数相关，表明矿化骨的丢失与软骨退变相关。由Elsevier Ltd代表国际骨关节炎研究协会出版。
Objective: To evaluate trabecular bone structure in relationship with cartilage parameters in distal femur and proximal tibia of the human knee at 3 Tesla (3 T) using high-resolution magnetic resonance imaging (MRI) with parallel imaging.Method: Sixteen healthy controls and 16 patients with mild osteoarthritis (OA) were studied using a 3 T magnetic resonance (MR) scanner and an eight-channel phased-array knee coil. Axial 3D GeneRalized Autocalibrating Partially Parallel Acquisition (GRAPPA)-based phase cycled Fast Imaging Employing Steady State Acquisition (FIFSTA-c) images were acquired in order to quantify the trabecular bone structure. For assessing cartilage morphology (thickness, volume), sagittal high-resolution 3D spoiled gradient echo (SPGR) images were acquired. In a subset of the subjects. sagittal images were acquired for measuring T1 rho and T2 relaxation times, using 3D T1 rho and T2 mapping techniques.Results: Good measurement reproducibility was observed for bone parameters, the coefficients of variations (CVs) ranging from 1.8% for trabecular number (app. Tb-N) to 5.5% for trabecular separation (app. Tb.Sp). Significant differences between control and CA groups were found for bone volume fraction bone volume over total volume (app. BV/TV) and app. Tb.Sp in all compartments. Significantly increased values in T1 rho and T2 were demonstrated in CA patients compared with controls at the femur, but not at the tibia. Tip was negatively correlated with app. BV/TV, app. Tb.N and app. Tb.Sp both at the medial femoral condyle (MFC) and lateral tibia (LT), while T2 was only correlated at the LT. Also, medial tibia (MT) T1 rho was negatively correlated with app. BV/TV (R-2 - 0.49, P < 0.05) and app. Tb.N (R-2 = -0.42, P < 0.05) from the opposite side of lateral femoral condyle (LFC). Significant correlations were found between trabecular bone parameters and cartilage thickness and normalized volume, mainly at LT, tibia (T) and femur (F).Conclusion: At this early stage of CA, an overall decrease in bone structure parameters and an increase in cartilage parameters (T1 rho, T2) were noticed in patients. Trabecular bone structure correlated with articular cartilage parameters suggesting that loss of mineralized bone is associated with cartilage degeneration. Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.