Susceptibility to Exercise-Induced Muscle Damage: a Cluster Analysis with a Large Sample
Susceptibility to Exercise-Induced Muscle Damage: a Cluster Analysis with a Large Sample
复制标题
DOI：
10.1055/s-0042-100281
复制
发表时间：
2016-07-01
影响因子：
2.5
通讯作者：
Ugrinowitsch, C.
中科院分区：
文献类型：
--
作者：
Damas, F.;Nosaka, K.;Ugrinowitsch, C.
我们在大量年轻男性（N = 286）中调查了运动引起的肌肉损伤（EIMD）的间接标记物的反应，这些标记物是基于不习惯的肘关节屈肌最大偏心运动后最大自愿收缩扭矩（MVC）的最大减少而分层的。比较基于MVC减少（低、中、高反应者；LR、MR和HR）建立的3个集群在运动前和运动后几天的MVC、肌肉酸痛（SOR）、肌酸激酶（CK）活性、活动范围（ROM）和上臂围（CIR）的变化。参与者被分配到LR (n = 61), MR （n = 152）和HR （n = 73）集群，它们分别描述了基线MVC的82%，61%和42%的显著不同的集群中心。一旦按MVC减少分层，所有肌肉损伤标志物在相同的模式下在集群之间显着不同：LR变化小，MR变化大，HR变化最大。基于运动后MVC下降幅度的个体分层大大提高了通过代理标记（如SOR、CK活性、ROM和CIR）估计EIMD变化的精度，这表明最常用的标记是有效的，MVC协调了他们的反应，巩固了MVC作为最佳EIMD间接标记的作用。
We investigated the responses of indirect markers of exercise-induced muscle damage (EIMD) among a large number of young men (N = 286) stratified in clusters based on the largest decrease in maximal voluntary contraction torque (MVC) after an unaccustomed maximal eccentric exercise bout of the elbow flexors. Changes in MVC, muscle soreness (SOR), creatine kinase (CK) activity, range of motion (ROM) and upper-arm circumference (CIR) before and for several days after exercise were compared between 3 clusters established based on MVC decrease (low, moderate, and high responders; LR, MR and HR). Participants were allocated to LR (n = 61), MR (n = 152) and HR (n = 73) clusters, which depicted significantly different cluster centers of 82 %, 61 % and 42 % of baseline MVC, respectively. Once stratified by MVC decrease, all muscle damage markers were significantly different between clusters following the same pattern: small changes for LR, larger changes for MR, and the largest changes for HR. Stratification of individuals based on the magnitude of MVC decrease post- exercise greatly increases the precision in estimating changes in EIMD by proxy markers such as SOR, CK activity, ROM and CIR. This indicates that the most commonly used markers are valid and MVC orchestrates their responses, consolidating the role of MVC as the best EIMD indirect marker.