Genetic content of Influenza H 3 N 2 vaccine seeds

Genetic content of Influenza H 3 N 2 vaccine seeds
复制标题

H 3 N 2 流感疫苗种子的基因含量

DOI:
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发表时间:
2017
期刊:
影响因子:
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通讯作者:
Bergeron
Bergeron
中科院分区:
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文献类型:
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作者:
Corinne Bergeron;bruno Lina Martine VALETTE;M. Ottmann;Bergeron

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从鸡蛋中制备的流感疫苗种子是通过HA和NA表面糖蛋白的抗原性和高复制能力来选择的。在这里,我们描述了最近使用的13种H3N2流感疫苗种子的遗传内容。有趣的是,对疫苗种子的序列分析显示,重组事件导致PR8:H3N2片段排列,从6:2到2:6排列。本研究表明,H3N2 PB1是被试疫苗种子中最常见的内部片段。
Influenza vaccine seeds produced in chicken eggs are selected through HA and NA surface glycoproteins antigenicity, as well as through high replicative ability. Here we characterize the genetic content of recently used thirteen H3N2 influenza vaccine seeds. Interestingly, sequence analysis of the vaccine seeds shows reassortment events leading to PR8:H3N2 segment constellations, ranging from the 6:2 to 2:6 constellations. This study shows that the H3N2 PB1 is the most frequent internal segment incorporated in the tested vaccines seeds.
DOI: 10.1016/j.vaccine.2009.06.024
发表时间: 2009-01-01
期刊: VACCINE
影响因子: 5.5
作者:
Liu, Jonathan;Shi, Xiao;Kemble, George
通讯作者: Kemble, George
在自然进化过程中,马 1 病毒中除基质外的内部蛋白质基因被马 2 流感病毒基因取代。
DOI: 10.1292/jvms.61.987
发表时间: 1999
期刊: The Journal of veterinary medical science
影响因子: --
作者:
Ito,T;Kawaoka,Y;Ohira,M;Takakuwa,H;Yasuda,J;Kida,H;Otsuki,K
通讯作者: Otsuki,K