Control of the gene optomotor-blind in Drosophila wing development by decapentaplegic and wingless
Control of the gene optomotor-blind in Drosophila wing development by decapentaplegic and wingless
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DOI：
10.1126/science.271.5255.1601
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发表时间：
1996-03-15
期刊：
影响因子：
56.9
通讯作者：
Pflugfelder, GO
中科院分区：
文献类型：
--
作者：
Grimm, S;Pflugfelder, GO
几个蛋白质家族的扩散因子控制昆虫和脊椎动物的附肢生长和图案化。在果蝇翅膀发育过程中，dpp基因沿着前后间隔边界表达。早期无翼（wg）表达参与建立背腹边界。表达dpp和wg的细胞之间的相互作用促进了附肢的生长。在这里，它表明，optomotor-blind（omb）的表达是需要远翼的发展，并控制的dpp和wg。异位的omb表达可以导致额外的翅膀的生长。因此，omb是翅膀发育所必需的，并由两个信号通路控制。
Diffusible factors of several protein families control appendage outgrowth and patterning in both insects and vertebrates. In Drosophila wing development, the gene decapentaplegic (dpp) is expressed along the anteroposterior compartment boundary. Early wingless (wg) expression is involved in setting up the dorsoventral boundary. Interaction between dpp- and wg-expressing cells promotes appendage outgrowth. Here, it is shown that optomotor-blind (omb) expression is required for distal wing development and is controlled by both dpp and wg. Ectopic omb expression can lead to the growth of additional wings. Thus, omb is essential for wing development and is controlled by two signaling pathways.