Identification of gametes and treatment of linear dependencies in the gametic QTL-relationship matrix and its inverse.
Identification of gametes and treatment of linear dependencies in the gametic QTL-relationship matrix and its inverse.
复制标题
DOI：
10.1186/1297-9686-36-6-621
复制
发表时间：
2004-11
期刊：
影响因子：
--
通讯作者：
Reinsch N
中科院分区：
文献类型：
--
作者：
Tuchscherer A;Mayer M;Reinsch N
通过标记辅助BLUP估计配子效应需要条件配子关系矩阵g的逆。每种动物的两个配子都可以通过标记或亲本来源来识别（区分）。通过实例证明，条件配子关系矩阵不是唯一的，而是取决于配子识别的方式。然而，每只动物的配子效应的总和——因此它的估计繁殖价值——仍然不受影响。为了消除G的行和列之间的依赖关系，推广了先前已知的建立G逆的算法。在存在依赖关系的情况下，G的秩也取决于配子识别的模式。将QTL基因型效应的估计转化为QTL配子效应被证明是不可能的。讨论了两种配子鉴定模式在应用领域的特点。
The estimation of gametic effects via marker-assisted BLUP requires the inverse of the conditional gametic relationship matrix G. Both gametes of each animal can either be identified (distinguished) by markers or by parental origin. By example, it was shown that the conditional gametic relationship matrix is not unique but depends on the mode of gamete identification. The sum of both gametic effects of each animal – and therefore its estimated breeding value – remains however unaffected. A previously known algorithm for setting up the inverse of G was generalized in order to eliminate the dependencies between columns and rows of G. In the presence of dependencies the rank of G also depends on the mode of gamete identification. A unique transformation of estimates of QTL genotypic effects into QTL gametic effects was proven to be impossible. The properties of both modes of gamete identification in the fields of application are discussed.