Elevated remnant-like lipoprotein particles in impaired glucose tolerance and type 2 diabetic patients
Elevated remnant-like lipoprotein particles in impaired glucose tolerance and type 2 diabetic patients
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DOI：
10.2337/diacare.22.1.152
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发表时间：
1999-01-01
期刊：
影响因子：
16.2
通讯作者：
Ishikawa, Y
中科院分区：
文献类型：
--
作者：
Watanabe, N;Taniguchi, T;Ishikawa, Y
目的：糖耐量受损(IGT)与胰岛素抵抗相关，被认为是动脉粥样硬化的危险因素。因此，IGT患者可能有异常的血脂和脂蛋白谱。这项研究的目的。为了解糖耐量减低(IGT)患者是否存在残留型高脂蛋白血症。研究设计与方法：对541例(男362例，女179例，年龄53+/-7.9岁)IGT患者血清残留样脂蛋白颗粒(RLP)水平进行检测。用含有抗人载脂蛋白A-I(H-12)和B-100(JI-H)抗体的免疫亲和凝胶测定RLP胆固醇(RLP-C)和RLP-甘油三酯(RLP-TG)。结果：在性别、年龄和体重匹配后，正常组、IGT组和糖尿病组的血清RLP-C分别为4.2+/-1.7、6.2+/-3.4和6.2+/-4.2 mg/dl，相应的RLP-TG值分别为16.7+/-9.2、28.0+/-19.1。29.0+/-27.2 mg/dl。我们发现糖耐量低减和糖尿病组的糖脂蛋白-C和糖脂蛋白-甘油三酯水平显著高于正常组(P<；0.001)。血清总胆固醇水平依次为206+/-29、205+/-34和206+/-34 mg/dl，低密度脂蛋白水平分别为127+/-27、124+/-34和123+/-34 mg/dl。在这些组中没有显示出显著差异。然而，糖耐量低减和糖尿病组的血清甘油三酯水平较高(分别为155+/-76和151+/-81 mg/dl vs.106+/-41 mg/dl；P<；0.0001)。此外，在正常胆固醇血症组中，IGT和糖尿病组残余高脂蛋白血症的发生率是正常组的4倍。结论-IGT和糖尿病患者血清RLP-C和RLP-TG水平升高可能代表这些患者动脉粥样硬化的风险增加。
OBJECTIVE - Impaired glucose tolerance (IGT) in association with insulin resistance is considered to be a risk factor for atherosclerosis. Thus, patients with IGT may have abnormal lipid and lipoprotein profiles. The purpose of this study. was to investigate presence of remnant-type hyperlipoproteinemia in patients with IGT.RESEARCH DESIGN AND METHODS - Serum levels of remnant like lipoprotein particles (RLP) were measured in 541 subjects (362 men and 179 women, age 53 +/- 7.9 years) who visited our health center for routine medical examinations. We measured RLP cholesterol (RLP-C) and RLP triglycerides (RLP-TG) using immunoaffinity gel containing monoclonal anti-human apoproteins A-I (H-12) and B-100 (JI-H) antibodies. After a 75-g oral glucose tolerance test, subjects were divided into three groups: normal, IGT, and type 2 diabetic.RESULTS - After matching for sex, age, and body weight, serum RLP-C in normal, IGT, and diabetic groups were 4.2 +/- 1.7, 6.2 +/- 3.4, and 6.2 +/- 4.2 mg/dl, respectively The corresponding RLP-TG values were 16.7 +/- 9.2, 28.0 +/- 19.1. and 29.0 +/- 27.2 mg/dl. We found that RLP-C and RLP-TG values were significantly higher in the IGT and diabetic groups compared with the normal group (P < 0.001). In the same order, total serum cholesterol levels were 206 +/- 29, 205 +/- 34, and 206 +/- 34 mg/dl and LDL cholesterol levels were 127 +/- 27, 124 +/- 34, and 123 +/- 34 mg/dl. showing no marked difference in these groups. However, serum levels of triglyceride were higher in the IGT and diabetes groups (155 +/- 76 and 151 +/- 81 mg/dl vs. 106 +/- 41 mg/dl; P < 0.0001). Further, the incidence of remnant hyperlipoproteinemia in normocholesterolemic subjects was up to four times higher in IGT and diabetic groups compared with the normal group.CONCLUSIONS - High serum RLP-C and RLP-TG levels in IGT and diabetic patients may represent an increased risk of atherosclerosis in these patients.