Anti-angiogenic properties of carnosol and carnosic acid, two major dietary compounds from rosemary
Anti-angiogenic properties of carnosol and carnosic acid, two major dietary compounds from rosemary
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DOI：
10.1007/s00394-011-0289-x
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发表时间：
2013-02-01
影响因子：
5
通讯作者：
Quesada, Ana R.
中科院分区：
文献类型：
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作者：
Lopez-Jimenez, Auxiliadora;Garcia-Caballero, Melissa;Quesada, Ana R.
迷迭香（Rosmarinus officinalis）叶及其成分作为膳食抗氧化剂和调味剂的来源的用途在不断增长。鼠尾草酚和鼠尾草酸是迷迭香提取物中的两种主要成分，具有抗癌和抗癌作用。本文研究了鼠尾草酚和鼠尾草酸的细胞毒性和抗血管生成活性，以进一步了解它们的作用机制。结果表明，上述二萜类化合物抑制内皮细胞的某些功能，即分化、增殖和凋亡。鼠尾草酚和鼠尾草酸的抗血管生成活性与它们的抗肿瘤活性密切相关。鼠尾草酚和鼠尾草酸的抗血管生成活性与它们迁移和蛋白水解能力。我们的数据表明，他们的生长抑制作用，施加在增殖的内皮细胞和肿瘤细胞，可能是由于，至少部分，诱导细胞凋亡。上述体外血管生成的基本步骤的抑制与所观察到的体内血管生成的抑制一致，证实了通过使用鸡绒尿囊膜assay.The鼠尾草酚和鼠尾草酸的抗血管生成活性可能有助于化学预防，抗肿瘤和抗转移活性的迷迭香提取物，并表明其在治疗其他血管生成相关的恶性肿瘤的潜力。
The use of rosemary (Rosmarinus officinalis) leaves and their constituents as a source of dietary antioxidants and flavoring agents is continuously growing. Carnosol and carnosic acid, two major components of rosemary extracts, have shown activity for cancer prevention and therapy.In this study, we investigate the cytotoxic and anti-angiogenic activities of carnosol and carnosic acid, in order to get further insight into their mechanism of action.Our results demonstrate that the mentioned diterpenes inhibit certain functions of endothelial cells, namely, differentiation, proliferation, migration and proteolytic capability. Our data indicate that their growth inhibitory effect, exerted on proliferative endothelial and tumor cells, could be due to, at least in part, an induction of apoptosis. Inhibition of the mentioned essential steps of in vitro angiogenesis agrees with the observed inhibition of the in vivo angiogenesis, substantiated by using the chick chorioallantoic membrane assay.The anti-angiogenic activity of carnosol and carnosic acid could contribute to the chemopreventive, antitumoral and antimetastatic activities of rosemary extracts and suggests their potential in the treatment of other angiogenesis-related malignancies.