Cumulative exposure assessment of neonicotinoids and an investigation into their intake-related factors in young children in Japan
Cumulative exposure assessment of neonicotinoids and an investigation into their intake-related factors in young children in Japan
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DOI：
10.1016/j.scitotenv.2020.141630
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发表时间：
2021-01-01
影响因子：
9.8
通讯作者：
Kamijima, Michihiro
中科院分区：
文献类型：
--
作者：
Oya, Naoko;Ito, Yuki;Kamijima, Michihiro
新烟碱类（NEO）在幼儿中的暴露水平尚不清楚，尽管它们的广泛使用以及幼儿对环境毒物的似是而非的脆弱性。本文旨在阐明日本儿童neo的暴露水平和来源。从2015年至2016年参与日本环境与儿童研究的1036名儿童（16-23个月大）中收集了一次性尿布。采用高效液相色谱-串联质谱法分析了从每个儿童尿布中提取的尿液中的6个neo和1个代谢物。采用一种相对效力因子方法来评估相当于呋喃水平的neo的累积暴露（DINRPF）。尿DINRPF第95百分位浓度为157 μ g/L，肌酐（Cr）为380 μ g/g。对可能的暴露相关因素倾向性得分进行的受试者工作特征曲线分析显示，决定调查当天摄入的每种食品的cr调整和cr未调整DINRPF浓度是否超过95百分位值的区分力（曲线下面积分别为0.62和0.75）高于暴露相关行为的区分力（0.60和0.71）。（分别为0.54和0.57）或母亲对食物选择和准备的态度。使用蚊蝇圈、驱蚊剂、纱门防虫网和在草坪上玩耍与尿NEO水平升高相关（比值比[OR]: 2.0-2.9），而母亲关心孩子的营养平衡会降低尿NEO水平（比值比：0.23-0.41）。据我们所知，这是第一项针对大量幼儿尿液中neo浓度和可能暴露源的研究。注意儿童的行为和饮食可能会减少幼儿对neo的高暴露。(C) 2020 Elsevier B.V.版权所有
Exposure levels of neonicotinoids (NEO) in young children remain unknown, despite their widespread use and the plausible vulnerability of toddlers to environmental toxicants. Hereinwe aimed to clarify the exposure levels and sources of NEOs in young Japanese children. Disposable diapers were collected from 1036 children (16-23 months old) participating in an adjunct study of the Japan Environment and Children's Study between 2015 and 2016. Six NEOs and one metabolite in urine extracted from a diaper from each child were analyzed using high-performance liquid chromatography-tandem mass spectrometry. A relative potency factor approach was used to assess the cumulative exposure to NEOs equivalent to dinotefuran levels (DINRPF). The 95th percentile urinary concentration of DINRPF was 157 mu g/L and 380 mu g/g creatinine (Cr). Receiver operating characteristic curve analyses for the propensity scores of the possible exposure-related factors revealed that the discriminatory powers determining whether Cr-adjusted and Cr-unadjusted DINRPF concentrations exceeding the 95th percentile values were higher for the amount of each foodstuff ingested on the survey day (areas under the curve were 0.62 and 0.75, respectively) than for the exposure-related behaviors (0.60 and 0.71, respectively) or formothers' attitudes toward food selection and preparation (0.54 and 0.57, respectively). Use of amosquito coil, insect repellent, and mothproof net for a screen door, and playing on a lawn were associated with increased urinary NEO levels (odds ratio [OR]: 2.0-2.9), while care about the child's nutritional balance bymothers reduced urinary NEO levels (OR: 0.23-0.41). To the best of our knowledge, this is the first study that dealtwith urinary concentrations and possible exposure sources of NEOs in a large number of young children. Attention to the children's behavior and diet might result in the reduction of a high exposure to NEOs in young children. (C) 2020 Elsevier B.V. All rights reserved.