Fine-mapping scan of bipolar disorder susceptibility loci in Latino pedigrees.
Fine-mapping scan of bipolar disorder susceptibility loci in Latino pedigrees.
复制标题
拉丁裔谱系中双相情感障碍易感位点的精细扫描。
DOI：
10.1002/ajmg.b.32715
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Escamilla,Michael
中科院分区：
文献类型：
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作者：
Gonzalez,Suzanne;Villa,Erika;Rodriguez,Marco;Ramirez,Mercedes;Zavala,Juan;Armas,Regina;Dassori,Albana;Contreras,Javier;Raventós,Henriette;Flores,Deborah;Jerez,Alvaro;Ontiveros,Alfonso;Nicolini,Humberto;Escamilla,Michael
We previously identified bipolar disorder (BD) susceptibility loci on 8q24, 14q32, and 2q12‐14 in a genome‐wide nonparametric linkage screen in a Latino cohort. We now perform a fine mapping analysis using a dense map of additional SNPs to identify BD susceptibility genes within these regions. One thousand nine hundred and thirty‐eight individuals with Latino ancestry (880 individuals with BD Type I or Schizoaffective, Bipolar Type) from 416 Latino pedigrees from the United States, Mexico, Costa Rica, and Guatemala were genotyped with 3,074 SNPs to provide dense coverage of the 8q24 (11.5 cM), 14q32 (7.5 cM), and 2q12‐14 (6.5 cM) chromosomal loci. Single‐marker association tests in the presence of linkage were performed using the LAMP software. The top linkage peak (rs7834818; LOD = 5.08,p= 3.30E − 5) and associated single marker (rs2280915,p= 2.70E − 12) were located within FBXO32 on 8q24. On chromosome 2, the top linkage peak (rs6750326; LOD = 5.06,p= 3.50E − 5) and associated single marker (rs11887088,p= 2.90E − 6) were located in intragenic regions near ACTR3 and DPP10. None of the additional markers in the region around chromosome 14q32 met significance levels for linkage or association. We identified six SNPs on 2q12‐q14 and one SNP in FBXO32 on 8q24 that were significantly associated with BD in this Latino cohort.
