Successful treatment of infliximab-associated immune-mediated sensory polyradiculopathy with intravenous immunoglobulin.
Successful treatment of infliximab-associated immune-mediated sensory polyradiculopathy with intravenous immunoglobulin.
复制标题
用静脉注射免疫球蛋白成功治疗英夫利昔单抗相关的免疫介导的感觉性多发性神经根病。
DOI：
10.1016/j.jocn.2012.12.016
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Shiio Y.
中科院分区：
文献类型：
--
作者：
Naruse H;Nagashima Y;Maekawa R;Etoh T;Hida A;Shimizu J;Kaida K;Shiio Y.
英夫利昔单抗是一种肿瘤坏死因子- α拮抗剂，用于治疗许多炎症性疾病。各种形式的脱髓鞘神经病变已被报道为与英夫利昔单抗使用相关的神经系统并发症。很少有与英夫利昔单抗相关的纯粹感觉神经病变的报道。我们报告一位亚急性感觉性多神经根病患者在英夫利昔单抗治疗寻常型银屑病1个月后的临床、电生理和病理结果。免疫介导的发病机制可能与抗神经节苷脂抗体阳性和静脉注射免疫球蛋白的快速反应有关。这是首例报道的在英夫利昔单抗治疗后出现抗神经节苷脂抗体阳性的感觉性多神经根病病例。我们的研究结果表明，在英夫利昔单抗治疗后，对脱髓鞘神经病变进行免疫学调查和治疗的临床重要性。
Infliximab, a tumor necrosis factor-alpha antagonist, is used to treat many inflammatory diseases. Various forms of demyelinating neuropathies have been reported as neurological complications associated with infliximab use. There have been few reports of pure sensory neuropathy associated with infliximab. We report the clinical, electrophysiological, and pathological findings of a patient with subacute sensory polyradiculopathy 1 month after infliximab therapy for psoriasis vulgaris. Immune-mediated pathogenesis was suggested by positive anti-ganglioside antibodies and rapid response to intravenous immunoglobulin. This is the first reported case of sensory polyradiculopathy with positive anti-ganglioside antibodies following infliximab therapy. Our findings suggest the clinical importance of immunological investigations and treatment in demyelinating neuropathies following infliximab therapy.