Hypertrophic effect of inhaled beta2-agonist with and without concurrent exercise training: A randomized controlled trial
Hypertrophic effect of inhaled beta2-agonist with and without concurrent exercise training: A randomized controlled trial
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DOI：
10.1111/sms.13221
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发表时间：
2018-10-01
影响因子：
4.1
通讯作者：
Hostrup, M.
中科院分区：
文献类型：
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作者：
Jessen, S.;Onslev, J.;Hostrup, M.
由于哮喘和运动诱发的支气管收缩在优秀运动员中的高患病率，在运动人群中存在β（2）-肾上腺素受体激动剂（β（2）-激动剂）的高使用。虽然啮齿类动物中存在合成代谢，但没有研究能够检测到慢性吸入β（2）-激动剂后人类的肥大。我们研究了吸入性β 2受体激动剂特布他林是否会改变健康年轻男性在同时进行运动训练和不进行运动训练的情况下的身体成分和代谢率。67名参与者完成了为期4周的每日特布他林（8x0.5mg）或安慰剂治疗干预，没有同时进行训练（习惯性; n=23），每周进行3次阻力（n=23）或耐力（n=21）训练。在干预前后，通过双能X射线吸收法测定参与者的身体成分，并通过间接量热法测定静息代谢率和底物氧化。特布他林使瘦体重增加1.03kg（95%CI 0.29-1.76; P
Due to a high prevalence of asthma and exercise-induced bronchoconstriction in elite athletes, there is a high use of beta(2)-adrenoceptor agonists (beta(2)-agonists) in the athletic population. While anabolic in rodents, no study has been able to detect hypertrophy in humans after chronic beta(2)-agonist inhalation. We investigated whether inhaled beta(2)-agonist, terbutaline, alters body composition and metabolic rate with and without concurrent exercise training in healthy young men. Sixty-seven participants completed a 4-week intervention of daily terbutaline (8x0.5mg) or placebo treatment without concurrent training (habitual; n=23), with resistance (n=23) or endurance (n=21) training 3 times weekly. Before and after the interventions, participant's body composition was determined by dual-energy X-ray absorptiometry and resting metabolic rate and substrate oxidation by indirect calorimetry. Terbutaline increased lean body mass by 1.03kg (95% CI 0.29-1.76; P