Anti-tumor necrosis factor therapy does not diminish the immune response to influenza vaccine in Japanese patients with rheumatoid arthritis.
Anti-tumor necrosis factor therapy does not diminish the immune response to influenza vaccine in Japanese patients with rheumatoid arthritis.
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DOI：
10.1007/s10165-007-0632-5
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发表时间：
2007-01-01
影响因子：
2.2
通讯作者：
Miyasaka, Nobuyuki
中科院分区：
文献类型：
--
作者：
Kubota, Tetsuo;Nii, Tokiko;Miyasaka, Nobuyuki
最近针对肿瘤坏死因子(TNF)的有效生物制剂在类风湿性关节炎(RA)治疗中的广泛应用提出了一个问题，即以这种方式治疗的患者是否对流感疫苗有正常反应。据我们所知，英语文献中只有几篇文章讨论这个问题，1-3，日本没有数据报告。因此，我们研究了接受/未接受抗肿瘤坏死因子生物制剂治疗的日本类风湿关节炎患者和健康对照组对流感疫苗的体液免疫反应。
The recent widespread employing of potent biologic agents targeting tumor necrosis factor (TNF) for the therapy of rheumatoid arthritis (RA) raises the question as to whether patients treated in this way respond normally to the influenza vaccine. To the best of our knowledge, there are only a few articles in the English language literature discussing this issue, 1–3 and no data have been reported from Japan. We therefore studied the humoral immune response to influenza vaccination in Japanese patients with RA who were treated/not treated with anti-TNF biologics in comparison with healthy controls.