Ethnic differences in the vasoconstrictor activity of endogenous endothelin-1 in hypertensive patients
Ethnic differences in the vasoconstrictor activity of endogenous endothelin-1 in hypertensive patients
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DOI：
10.1161/01.cir.0000130590.24107.d3
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发表时间：
2004-06-29
期刊：
影响因子：
37.8
通讯作者：
Panza, JA
中科院分区：
文献类型：
--
作者：
Campia, U;Cardillo, C;Panza, JA
黑人原发性高血压的发病机制可能与白人不同。特别是，黑人患者通常表现为盐敏感的低肾素形式，在动物模型中与内皮素-1（ET-1）活性增强有关。本研究的目的是评估是否存在种族差异，在血管活性的ET-1在血压正常和高血压的黑人和white.Methods和结果前臂血流（FBF）反应动脉灌注的ETA受体阻滞剂（BQ-123）进行了分析，体积描记法在37名血压正常的患者和27名高血压患者根据种族。BQ-123不影响正常血压受试者的FBF（P=0.30），而对高血压受试者产生显著的血管舒张作用（P
Background-The pathogenesis of essential hypertension in blacks may differ from that in whites. In particular, black patients usually present with a salt-sensitive, low-renin form, which in animal models is associated with enhanced activity of endothelin-1 (ET-1). This study aimed to assess whether ethnic differences exist in the vascular activity of ET-1 in normotensive and hypertensive blacks and whites.Methods and Results-Forearm blood flow (FBF) responses to intraarterial infusion of an ETA receptor blocker (BQ-123) were analyzed by plethysmography in 37 normotensive patients and 27 hypertensive patients according to race. BQ-123 did not affect FBF in normotensive subjects (P=0.30), whereas it produced significant vasodilation in hypertensive subjects (P