The Utility of Animal Models in Understanding Links between Psychosocial Processes and Cardiovascular Health.
The Utility of Animal Models in Understanding Links between Psychosocial Processes and Cardiovascular Health.
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DOI：
10.1111/j.1751-9004.2011.00342.x
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发表时间：
2011-04
影响因子：
4.6
通讯作者：
Grippo AJ
中科院分区：
文献类型：
--
作者：
Grippo AJ
情绪障碍和心血管疾病之间的双向关联已被描述；然而，这种联系背后的神经生物学机制尚未完全阐明。本综述的目的首先是描述情绪和心血管疾病常见的一些重要的行为神经生物学过程。其次，本综述重点关注用动物模型（主要是啮齿类动物）进行研究的价值，以调查情绪障碍和心血管疾病之间的潜在行为、生理和神经过程。结合人类研究的结果，使用动物模型研究情绪和心血管调节的机制将增强我们对抑郁症和心血管疾病之间关系的理解，并可以促进针对患有这些共病的个体开发新的干预措施。
A bidirectional association between mood disorders and cardiovascular disease has been described; however, the neurobiological mechanisms that underlie this link have not been fully elucidated. The purpose of this review is first to describe some of the important behavioral neurobiological processes that are common to both mood and cardiovascular disorders. Second, this review focuses on the value of conducting research with animal models (primarily rodents) to investigate potential behavioral, physiological, and neural processes involved in the association of mood disorders and cardiovascular disease. In combination with findings from human research, the study of mechanisms underlying mood and cardiovascular regulation using animal models will enhance our understanding of the association of depression and cardiovascular disease, and can promote the development of novel interventions for individuals with these comorbid conditions.