Thyroid Disruption by Low-Dose BDE-47 in Prenatally Exposed Lambs
Thyroid Disruption by Low-Dose BDE-47 in Prenatally Exposed Lambs
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DOI：
10.1159/000209316
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发表时间：
2009-01-01
期刊：
影响因子：
2.5
通讯作者：
Takser, Larissa
中科院分区：
文献类型：
--
作者：
Abdelouahab, Nadia;Suvorov, Alexander;Takser, Larissa
本研究的目的是评估多溴联苯醚（PBDE）在报告的人群水平是否会影响怀孕绵羊和羔羊的甲状腺状态。怀孕的绵羊分别接触溶剂或BDE-47（0.2、2和20微克/千克体重）。从妊娠第5至第15周每周静脉注射。对绵羊和羔羊血液及脂肪组织中的甲状腺激素水平和BDE-47含量进行了分析。我们观察到暴露羔羊的总T-4和T-3显著降低，而对妊娠绵羊无任何影响。我们的研究结果表明，产前低剂量的多溴联苯醚暴露导致多溴联苯醚在后代的脂肪中储存，并影响发育中胎儿的甲状腺代谢。版权所有（C）2009 S. Karger AG，巴塞尔
The purpose of this study was to evaluate whether polybrominated diphenyl ethers (PBDE) at levels reported for human populations affect the thyroid state in pregnant sheep and lambs. Pregnant sheep were exposed to vehicle or BDE-47 (0.2, 2 and 20 mu g/kg b.w.) from the 5th to 15th week of gestation by intravenous injections weekly. Thyroid hormone levels and BDE-47 content in the blood of sheep and lambs and adipose tissue were analyzed. We observed a significant decrease in total T-4 and T-3 in exposed lambs without any effect in pregnant sheep. Our finding indicates that prenatal low-dose PBDE exposure results in PBDE storage in fat of offspring and can affect thyroid metabolism in the developing fetus. Copyright (C) 2009 S. Karger AG, Basel