Age-dependent loss of accommodative amplitude in rhesus monkeys: an animal model for presbyopia.
Age-dependent loss of accommodative amplitude in rhesus monkeys: an animal model for presbyopia.
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DOI：
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发表时间：
1982-07
影响因子：
4.4
通讯作者：
L. Bito;C. J. Derousseau;P. Kaufman;J. W. Bito
中科院分区：
文献类型：
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作者：
L. Bito;C. J. Derousseau;P. Kaufman;J. W. Bito
在123只年龄从0.5岁到30岁以上的笼养恒河猴中，在休息和完全调节的条件下测量了眼的屈光力和眼轴尺寸。在氯胺酮麻醉下测量的平均静息屈光度为-5屈光度。屈光度振幅，计算为静息屈光度和最负的屈光度之间的差异测量0.5至1小时后，局部应用最大有效剂量的拟胆碱酯酶，表现出年龄依赖性下降。1 ~ 5岁猕猴的平均调节幅度为34 D，而25岁以上的猕猴的平均调节幅度为5 D。一些大于25岁的动物没有表现出可测量的屈光变化，无论使用的拟胆碱药物的剂量或类型（卡巴胆碱、毛果芸香碱或乙硫氨酸）如何。透镜的静止轴向厚度被发现在整个成年期随年龄增加，以及过去的生长期结束。一个很强的相关性，发现之间的激光诱导的变化，在眼睛的屈光力和改变晶状体厚度。这些与人类的相似之处表明，恒河猴是研究调节和老花眼的非常合适的动物模型。
The refractive power and axial dimensions of the eye were measured under resting and fully accommodated conditions in 123 caged rhesus monkeys ranging in age from 0.5 to greater than 30 years. The mean resting refraction measured under ketamine anesthesia was -5 diopters. Accommodative amplitude, calculated as the difference between resting refraction and the most negative refraction measured 0.5 to 1 hr after topical application of a maximally effective dose of a cholinomimetic, showed an age-dependent decline. The mean accommodative amplitude of 1- to 5-year-old rhesus monkeys was a remarkable 34 D, while animals over 25 years of age averaged 5 D of accommodation. Some greater than 25-year-old animals showed no measurable change in refraction regardless of the dose or the type of cholinomimetic (carbachol, pilocarpine, or echothiophate) used. The resting axial thickness of the lens was found to increase with age throughout adulthood, well past the end of the growth period. A strong correlation was found between pharmacologically induced change in the refractive power of the eye and change in lenticular thickness. These similarities to the human condition suggest that the rhesus monkey represents a highly suitable animal model for the study of accommodation and presbyopia.