Gene signatures in peripheral blood immune cells related to insulin resistance and low tyrosine metabolism define a sub-type of depression with high CRP and anhedonia
Gene signatures in peripheral blood immune cells related to insulin resistance and low tyrosine metabolism define a sub-type of depression with high CRP and anhedonia
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DOI：
10.1016/j.bbi.2020.03.015
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发表时间：
2020-08-01
影响因子：
15.1
通讯作者：
Felger, Jennifer C.
中科院分区：
文献类型：
--
作者：
Bekhbat, Mandakh;Treadway, Michael T.;Felger, Jennifer C.
炎症和葡萄糖代谢改变是重性抑郁症（MDD）病理生理学中的两个途径。我们先前已经表明，在MDD患者中，通过C反应蛋白（CRP）测量的高度炎症与快感缺乏症状（MDD的核心症状）相关，沿着多巴胺能奖赏回路的缺陷。炎症增加可以改变代谢需求并重新编程细胞能量来源，这可能会共同影响大脑并奖励处理，从而导致快感缺乏的症状。为了确定免疫代谢基因特征是否在伴有炎症增加和快感缺乏的抑郁症患者的免疫细胞中富集，我们检查了来自未经药物治疗的医学稳定的MDD患者（n = 93）的全血基因表达微阵列（Illumina HumanHT-12）数据。根据高（> 3 mg/L）与低（
Inflammation and altered glucose metabolism are two pathways implicated in the pathophysiology of major depressive disorder (MDD). We have previously shown that high inflammation as measured by C-reactive protein (CRP) in MDD patients is associated with symptoms of anhedonia, a core symptom of MDD, along with deficits in dopaminergic reward circuitry. Increased inflammation can shift metabolic demand and reprogram cellular energy sources, which may collectively impact the brain and reward processing to contribute to symptoms of anhedonia. To determine whether immunometabolic gene signatures were enriched in immune cells of depressed patients with increased inflammation and anhedonia, we examined whole-blood gene expression microarray (Illumina HumanHT-12) data from unmedicated, medically-stable patients with MDD (n = 93). Patients were considered to have increased inflammation based on High (>3mg/L) versus Low (