Rationale and methods of the Advanced R2Eperfusion STrategies for Refractory Cardiac Arrest (ARREST) trial
Rationale and methods of the Advanced R2Eperfusion STrategies for Refractory Cardiac Arrest (ARREST) trial
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DOI：
10.1016/j.ahj.2020.07.006
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发表时间：
2020-11-01
影响因子：
4.8
通讯作者：
Aufderheide, Tom P.
中科院分区：
文献类型：
--
作者：
Yannopoulos, Demetris;Kalra, Rajat;Aufderheide, Tom P.
背景：静脉动脉体外膜肺氧合已成为难治性心脏骤停患者的重要治疗方法。目的评估成人难治性室颤/无脉室性心动过速院外心脏骤停患者的出院存活率，采用两种局部护理标准中的一种：(1)早期静脉动脉体外膜氧合复苏循环支持和经皮冠状动脉介入治疗，或(2)标准的高级心脏生命支持复苏。设计II期，单中心，部分失明，前瞻性，意向治疗，安全性和有效性临床试验。室颤/无脉性室性心动过速的初始院外心脏骤停节律，3次电击后无ROSC，适应隆德大学心脏骤停系统自动心肺复苏装置的身体形态，以及转移时间
Background Venoarterial extracorporeal membrane oxygenation has emerged as a prominent therapy for patients with refractory cardiac arrest. However, the optimal time of initiation remains unknown.Aim The aim was to assess the rate of survival to hospital discharge in adult patients with refractory ventricular fibrillation/pulseless ventricular tachycardia out-of-hospital cardiac arrest treated with 1 of 2 local standards of care: (1) early venoarterial extracorporeal membrane oxygenation-facilitated resuscitation for circulatory support and percutaneous coronary intervention, when needed, or (2) standard advanced cardiac life support resuscitation.Design Phase II, single-center, partially blinded, prospective, intention-to-treat, safety and efficacy clinical trial.Population Adults (aged 18-75), initial out-of-hospital cardiac arrest rhythm of ventricular fibrillation/pulseless ventricular tachycardia, no ROSC following 3 shocks, body morphology to accommodate a Lund University Cardiac Arrest System automated cardiopulmonary resuscitation device, and transfer time of