Tailored Surface Treatment of 3D Printed Porous Ti6Al4V by Microarc Oxidation for Enhanced Osseointegration via Optimized Bone In-Growth Patterns and Interlocked Bone/Implant Interface
Tailored Surface Treatment of 3D Printed Porous Ti6Al4V by Microarc Oxidation for Enhanced Osseointegration via Optimized Bone In-Growth Patterns and Interlocked Bone/Implant Interface
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通过微弧氧化对 3D 打印多孔 Ti6Al4V 进行定制表面处理，通过优化骨生长模式和联锁骨/种植体界面增强骨整合
DOI：
10.1021/acsami.6b05893
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发表时间：
2016
影响因子：
9.5
通讯作者：
Liu Zhongjun
中科院分区：
文献类型：
--
作者：
Xiu Peng;Jia Zhaojun;Lv Jia;Yin Chuan;Cheng Yan;Zhang Ke;Song Chunli;Leng Huijie;Zheng Yufeng;Cai Hong;Liu Zhongjun
3D打印多孔钛（Ti）在承重骨科应用中具有巨大的潜力。尽管3D打印技术可以很好地控制多孔钛的宏观结构，但影响组织响应的表面特性超出了3D打印技术的控制范围，这就增加了对其进行定制表面处理以提高其骨整合能力的需求。在这里，一步微弧氧化（MAO）工艺应用于3D打印多孔Ti6Al4V （Ti64）支架，赋予支架均匀的微孔tio2层和大量的无定形磷酸钙。经过处理后，多孔Ti64支架的磷灰石形成能力、细胞相容性和碱性磷酸酶活性显著提高。兔模型体内实验表明，未处理支架的骨生长呈距离成骨模式，仅在支架周边形成骨。相比之下，mao处理的支架的骨生长表现出一种接触成骨的模式，通过这种模式，骨在支架的整个表面原位形成。这种骨生长模式显著增加了支架内部和周围的骨形成，可能是通过增强骨形成和破坏骨重塑。此外，mao处理支架的种植体表面通过制备的微孔形貌与骨组织互锁，从而产生更强的骨/种植体界面。推出试验进一步证实了骨整合强度的增加。MAO通过优化骨生长模式和骨/种植体互锁，在增强多孔Ti64的骨整合方面表现出高效率。因此，利用MAO技术对3D打印多孔Ti64进行后处理，可能为骨科应用中生物活性定制植入物的开发开辟了几种可能性。
3D printed porous titanium (Ti) holds enormous potential for load-bearing orthopedic applications. Although the 3D printing technique has good control over the macro-sturctures of porous Ti, the surface properties that affect tissue response are beyond its control, adding the need for tailored surface treatment to improve its osseointegration capacity. Here, the one step microarc oxidation (MAO) process was applied to a 3D printed porous Ti6Al4V (Ti64) scaffold to endow the scaffold with a homogeneous layer of microporous TiO2and significant amounts of amorphous calcium-phosphate. Following the treatment, the porous Ti64 scaffolds exhibited a drastically improved apatite forming ability, cyto-compatibility, and alkaline phosphatase activity. In vivo test in a rabbit model showed that the bone in-growth at the untreated scaffold was in a pattern of distance osteogenesis by which bone formed only at the periphery of the scaffold. In contrast, the bone in-growth at the MAO-treated scaffold exhibited a pattern of contact osteogenesis by which bone formed in situ on the entire surface of the scaffold. This pattern of bone in-growth significantly increased bone formation both in and around the scaffold possibly through enhancement of bone formation and disruption of bone remodeling. Moreover, the implant surface of the MAO-treated scaffold interlocked with the bone tissues through the fabricated microporous topographies to generate a stronger bone/implant interface. The increased osteoinetegration strength was further proven by a push out test. MAO exhibits a high efficiency in the enhancement of osteointegration of porous Ti64 via optimizing the patterns of bone in-growth and bone/implant interlocking. Therefore, post-treatment of 3D printed porous Ti64 with MAO technology might open up several possibilities for the development of bioactive customized implants in orthopedic applications.