Trajectories of growth among children who have coronary events as adults
Trajectories of growth among children who have coronary events as adults
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DOI：
10.1056/nejmoa044160
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发表时间：
2005-10-27
影响因子：
158.5
通讯作者：
Eriksson, JG
中科院分区：
文献类型：
--
作者：
Barker, DJP;Osmond, C;Eriksson, JG
背景：低出生体重是冠心病的危险因素。目前尚不确定出生后发育如何影响疾病风险。方法：我们研究了从1934年到1944年出生在赫尔辛基的8760人。儿童时期的成长已被记录在案。共有357名男性和87名女性因冠心病入院或死于冠心病。结果：成年后有冠状动脉事件的儿童出生时的平均体型低于平均水平。这些儿童在两岁时很瘦；随后，他们的身体质量指数(BMI)相对于其他儿童有所增加，并在11岁时达到平均值。在同时回归分析中，体重指数每增加1 SD的危险比为0.76(95%可信区间为0.66~0.87；P
BACKGROUND:Low birth weight is a risk factor for coronary heart disease. It is uncertain how postnatal growth affects disease risk.METHODS:We studied 8760 people born in Helsinki from 1934 through 1944. Childhood growth had been recorded. A total of 357 men and 87 women had been admitted to the hospital with coronary heart disease or had died from the disease. Coronary risk factors were measured in a subset of 2003 people.RESULTS:The mean body size of children who had coronary events as adults was below average at birth. At two years of age the children were thin; subsequently, their body-mass index (BMI) increased relative to that of other children and had reached average values by 11 years of age. In simultaneous regressions, the hazard ratios associated with a 1 SD increase in BMI were 0.76 (95 percent confidence interval, 0.66 to 0.87; P