The value of resting-state functional MRI in subacute ischemic stroke: comparison with dynamic susceptibility contrast-enhanced perfusion MRI.
The value of resting-state functional MRI in subacute ischemic stroke: comparison with dynamic susceptibility contrast-enhanced perfusion MRI.
复制标题
静息态功能MRI在亚急性缺血性卒中中的价值：与动态磁敏感对比增强灌注MRI的比较
DOI：
10.1038/srep41586
复制
发表时间：
2017-01-31
影响因子：
4.6
通讯作者：
Xu Y
中科院分区：
文献类型：
--
作者：
Ni L;Li J;Li W;Zhou F;Wang F;Schwarz CG;Liu R;Zhao H;Wu W;Zhang X;Li M;Yu H;Zhu B;Villringer A;Zang Y;Zhang B;Lv Y;Xu Y
通过对比动态敏感性对比灌注加权成像（DSC-PWI），评价静息状态fMRI （rs-fMRI）血氧水平依赖（BOLD）数据时移分析（TSA）方法检测亚急性脑卒中患者灌注不足的潜在临床价值。40例亚急性脑卒中患者（神经症状出现后3 ~ 14天）行MRI检查。队列A: 31例患者有MRA、DSC-PWI和BOLD数据。队列B: 9例患者有BOLD和MRA数据。利用TSA计算每个体素的BOLD时间过程与全局和对侧半球平均信号之间的时间延迟。采用峰值时间（Time to peak， TTP）检测灌注不足。在A队列中，14例伴侧络稀疏的颅内大血管闭塞/狭窄患者两种入路均表现为灌注不足，1例伴侧络丰富的患者均未表现为TTP和TSA时间延迟。其余16例无明显MRA病变的患者均未出现TTP和TSA时间延迟。在B队列中，8例患者出现时间延迟区。对于MRA病变明显且络稀疏的亚急性脑卒中患者，TSA方法是一种有希望的替代DSC-PWI检测灌注不足的方法，络丰富的患者可保持局部灌注完整。
To evaluate the potential clinical value of the time-shift analysis (TSA) approach for resting-state fMRI (rs-fMRI) blood oxygenation level-dependent (BOLD) data in detecting hypoperfusion of subacute stroke patients through comparison with dynamic susceptibility contrast perfusion weighted imaging (DSC-PWI). Forty patients with subacute stroke (3–14 days after neurological symptom onset) underwent MRI examination. Cohort A: 31 patients had MRA, DSC-PWI and BOLD data. Cohort B: 9 patients had BOLD and MRA data. The time delay between the BOLD time course in each voxel and the mean signal of global and contralateral hemisphere was calculated using TSA. Time to peak (TTP) was employed to detect hypoperfusion. Among cohort A, 14 patients who had intracranial large-vessel occlusion/stenosis with sparse collaterals showed hypoperfusion by both of the two approaches, one with abundant collaterals showed neither TTP nor TSA time delay. The remaining 16 patients without obvious MRA lesions showed neither TTP nor TSA time delay. Among cohort B, eight patients showed time delay areas. The TSA approach was a promising alternative to DSC-PWI for detecting hypoperfusion in subacute stroke patients who had obvious MRA lesions with sparse collaterals, those with abundant collaterals would keep intact local perfusion.