Progressive alcohol-induced sperm alterations leading to spermatogenic arrest, which was reversed after alcohol withdrawal
Progressive alcohol-induced sperm alterations leading to spermatogenic arrest, which was reversed after alcohol withdrawal
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DOI：
10.1016/j.rbmo.2009.12.003
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发表时间：
2010-03-01
影响因子：
4
通讯作者：
Mandelbaum, Jacqueline
中科院分区：
文献类型：
--
作者：
Sermondade, Nathalie;Elloumi, Hanene;Mandelbaum, Jacqueline
本文报告了一位配偶患者在重度慢性酒精中毒期间和戒酒后6年的精液参数的随访。可以观察到酒精的缓慢进展的负面影响：孤立性中度畸精症首先被发现，紧随其后的是少弱畸精症。然后病情的严重恶化导致了隐精症，并最终导致了无精子症。此时，睾丸活检的组织学分析显示粗线期生发细胞成熟停滞，没有成熟的精子细胞。然后进行酒精戒断，使精液特征得到非常迅速和显著的改善；在不超过3个月的时间内观察到严格正常的精液参数。考虑到这些数据，患者应该在辅助生殖技术之前询问他们的酒精摄入量，并应该被告知这种不良影响。此外，这份案例报告强调，即使在长期大量饮酒的情况下，戒酒后也能很快获得好处。(C)2010，爱思唯尔有限公司出版的《生殖健康有限公司》。版权所有
This is a report of a 6-year follow-up of a mate patient's semen parameters during heavy chronic alcohol intoxication and after withdrawal. A slowly progressive negative impact of alcohol could be observed: isolated moderate teratozoospermia was firstly noted followed by oligoasthenoteratospermia. Then a severe worsening resulted in cryptozoospermia and ultimately in azoospermia. At this moment, the histological analysis of a testicular biopsy revealed a maturation arrest of the germinal cells at the pachytene stage with no mature sperm cells. Alcohol withdrawal was then obtained, allowing a very fast and drastic improvement of semen characteristics; strictly normal semen parameters were observed after no more than 3 months. Taking into consideration these data, patients should be questioned about their alcohol intake before assisted reproductive technology and should be informed about this adverse effect. Moreover, this case report emphasizes how quickly benefits can be obtained after withdrawal, even in the case of heavy chronic alcohol intake. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved