Ribonucleoprotein Ribonucleases P and MRP
Ribonucleoprotein Ribonucleases P and MRP
复制标题
DOI：
10.1007/978-3-642-21078-5_13
复制
发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Krasilnikov, Andrey S.
中科院分区：
文献类型：
--
作者：
Krasilnikov, Andrey S.
核糖核蛋白核糖核酸酶（RNase） P和RNase MRP由一个大的RNA组分和一个必需的蛋白质部分组成。核糖核酸酶P/MRP不同于所有其他已知的核糖核酸酶，因为它是它们的RNA成分，而不是蛋白质，负责底物的核内溶裂解。RNase P在生命的所有三个领域中都是普遍必需的；密切相关的RNase MRP是一种普遍存在的真核酶。RNase P主要负责tRNA 5'端的成熟，而RNase MRP则参与真核生物rRNA的成熟和特定mrna的降解。本文讨论了rna酶P/MRP的功能、结构组织、底物识别和催化机制。
Ribonucleoprotein Ribonuclease (RNase) P and RNase MRP consist of a large RNA component and an essential protein part. RNases P/MRP differ from all other known ribonucleases in that it is their RNA component, not protein that is responsible for the endonucleolytic cleavage of substrates. RNase P is universally essential in all three domains of life; the closely related RNase MRP is a ubiquitous eukaryotic enzyme. RNase P is primarily responsible for the maturation of the 5'-ends of tRNA, whereas RNase MRP is known to be involved in the maturation of eukaryotic rRNA and the degradation of specific mRNAs. Here we discuss available information on functions, structural organization, and mechanisms of substrate recognition and catalysis of RNases P/MRP.